Current Advances in Synthesis of Pyrazole Derivatives: An Approach Toward Energetic Materials

Abstract

Pyrazole derivatives are strategic structural motifs due to their proven utility in preparing chemicals in biological, pharmaceutical, photophysical, technological, and industrial fields; therefore, syntheses of pyrazole-containing compounds are highly desirable. Some nitrogen-rich pyrazoles, specifically nitrated derivatives posing high density and moderate thermal stability, have been used as energetic compounds since a high amount of energy is stored in their structures that can be released quickly with high detonation power under external stimuli (i.e., thermal, impact, and friction). These compounds have good capacity and sensitivity in explosives, propellants, and pyrotechnics applications in eco-friendly ways. Therefore, this contribution focuses on recent and illustrative examples regarding the (i) synthesis and reactivity of pyrazoles, especially works of the last decade, highlighting works on (ii) applications in energetic compounds to analyze their scope.