Lewis Base Promoted [4+2] Annulation of o-Acylamino-Aryl Morita-Baylis-Hillman Carbonates With Isatylidene Malononitriles: Facile Access to Spiro[Indolin-3,2′-Quinoline] Frameworks
Li-Wen Shen, Mao-Dan Luo, Wen-Yi Zhou, Yuan-Ying Luo, Min Xiang, Yun-Qing Jia, Shu-Pei Yuan, Guang-Wei Wang
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Abstract
A novel [4+2] annulation reaction between o-acylamino-aryl MBH carbonates and isatylidene malononitriles has been successfully developed. This methodology exhibits excellent substrate tolerance, affording a series of spiro[indolin-3,2′-quinoline] framework compounds with yields up to 98%. The scalability of the reaction is also noteworthy, as evidenced by the 95% yield of the final product upon a 50-fold scale-up.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
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