{"title":"Radical C4−H Arylation of 1,4-Dihydropyridines with Cyanoarenes","authors":"Huaixuan Guo, Shiqin Qiu, Peng Xu","doi":"10.1002/hlca.202400162","DOIUrl":null,"url":null,"abstract":"<p>4-Aryl-1,4-dihydropyridines are prevalent pharmacophores and versatile building blocks in medicinal and synthetic chemistry. Herein, we demonstrated a mechanistically distinct radical-radical cross-coupling approach to 4-aryl-1,4-dihydropyridines, via direct C4−H arylation of 1,4-dihydropyridines with readily available cyanoarenes. This mild protocol is initiated by the direct photoexcitation of 1,4-dihydropyridines, eliminating the need for expensive photocatalysts and enabling operation under ambient air conditions.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"107 12","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Helvetica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hlca.202400162","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
4-Aryl-1,4-dihydropyridines are prevalent pharmacophores and versatile building blocks in medicinal and synthetic chemistry. Herein, we demonstrated a mechanistically distinct radical-radical cross-coupling approach to 4-aryl-1,4-dihydropyridines, via direct C4−H arylation of 1,4-dihydropyridines with readily available cyanoarenes. This mild protocol is initiated by the direct photoexcitation of 1,4-dihydropyridines, eliminating the need for expensive photocatalysts and enabling operation under ambient air conditions.
期刊介绍：
Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.
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