Organic photoelectrochemical transistor based on titanium dioxide nanorods for detection of Microcystin-LR

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL Talanta Pub Date : 2024-12-16 DOI:10.1016/j.talanta.2024.127401

Jiahe Chen, Jiaxin Lv, Yue Liu, Jia-Hao Chen, Xue Wang, Hong Zhou

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Abstract

A more efficient signal amplification strategy is needed to improve the performance of promising photoelectrochemical sensors (PEC). Organic photoelectrochemical transistor (OPECT) sensors are of growing interest in many fields, but their potential has not yet been widely exploited and remains a challenge. In this study, a novel organic photoelectrochemical transistor aptamer (OPECT) biosensor combining photoelectrochemical analysis and organic electrochemical transistor with AgI–TiO₂ (AgI-TNs) as photoreactive material and target-specific DNA chain reaction hybridization as signal amplifier for microcystin-LR detection was developed. The developed sensor performs highly sensitive detection with a linear range of 0.1 fg mL⁻¹-10 pg mL⁻¹ and a low detection limit of 0.079 fg mL⁻¹. The development of the biosensitive OPECT platform is a promising tool for MC-LR detection, meanwhile it can also be used to detect other contaminants in freshwater environments.

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基于二氧化钛纳米棒的有机光电化学晶体管用于检测微囊藻毒素-LR。

为了提高光电化学传感器的性能，需要一种更有效的信号放大策略。有机光电电化学晶体管（OPECT）传感器在许多领域受到越来越多的关注，但其潜力尚未得到广泛开发，仍然存在挑战。本研究将光电化学分析与有机电化学晶体管结合，以AgI-TiO2 （AgI-TNs）为光反应材料，以靶向DNA链反应杂交作为信号放大器，开发了一种新型的有机光电电化学晶体管适体（OPECT）生物传感器，用于微囊藻毒素lr检测。该传感器具有高灵敏度的检测，线性范围为0.1 fg mL-1-10 pg mL-1，低检测限为0.079 fg mL-1。生物敏感OPECT平台的开发是一种很有前途的MC-LR检测工具，同时它也可以用于检测淡水环境中的其他污染物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.