Brief Report: Pancreatic Cancer in People With HIV: A Case-Control Study.

IF 2.9 3区医学 Q3 IMMUNOLOGY JAIDS Journal of Acquired Immune Deficiency Syndromes Pub Date : 2025-04-01 DOI:10.1097/QAI.0000000000003585

Sylvain Chawki, Gwenn Hamet, Alexandre Brun, Nelson Lourenco, Olivier Bouchaud, Julie Bottero, Pierre Sellier, Jean-Michel Molina

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Abstract

Background: We aimed to estimate the incidence and to assess the risk factors associated with pancreatic cancer (PC) in people with HIV (PWH).

Setting: We used electronic medical record data from 2009 to 2020 available in the COREVIH Ile-de-France-Est database of PWH treated in Paris public hospitals.

Methods: We analyzed data on patient demographics, treatment history, and immunovirologic status. A case-control study was designed; each case (PWH and PC) was matched on age, gender, and duration of HIV infection to 4 controls (PWH without PC).

Results: Twenty-four cases were identified from the database, with an incidence of PC estimated at 28 cases (95% confidence interval: 19 to 43) per 100,000 person-years. The median age was 57 years [interquartile range (IQR) 51-68] at cancer diagnosis. Twenty-one cases (88%) were male. The median CD4 + T-cell count at PC diagnosis was 587/mm 3 (IQR 317-748), and the nadir CD4 + T-cell count was 194 (IQR 98-380). Twenty cases (91%) had a suppressed HIV replication at PC diagnosis. Twelve patients (50%) had metastasis on diagnosis. The median time to death after cancer diagnosis was 11 months (IQR 1-19). Twenty-two cases were matched with 88 controls. There were no statistically significant risk factors of PC identified in our analysis.

Conclusion: PC remains rare in PWH and is associated with a severe prognosis at a relatively young age. Further studies are needed to identify risk factors associated with PC development in PWH.

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艾滋病毒感染者胰腺癌：一项病例对照研究。

背景：我们的目的是估计艾滋病毒感染者（PWH）胰腺癌（PC）的发病率和评估相关的危险因素。背景：我们使用了2009年至2020年在巴黎公立医院治疗的PWH的COREVIH Ile-de-France Est数据库中提供的电子病历数据。方法：我们分析了患者人口统计学、治疗史和免疫病毒学状态的数据。设计病例-对照研究，每个病例（PWH和PC）在年龄、性别和感染时间上与4个对照组（PWH和PC）相匹配。结果：从数据库中确定了24例，PC的发病率估计为每10万人每年28例（95%CI[19-43]）。癌症诊断时中位年龄为57岁（IQR[51-68]）。男性21例（88%）。PC诊断时CD4+ T细胞计数中位数为587/mm3 (IQR[317-748])，最低CD4+ T细胞计数为194 （IQR[98-380]）。20例（91%）在PC诊断时HIV复制受到抑制。12例（50%）确诊时已发生转移。癌症诊断后至死亡的中位时间为11个月[IQR 1-19]。22例与88例对照。在我们的分析中没有发现统计学上显著的PC危险因素。结论：胰腺癌在PWH中仍然很少见，并且在相对年轻的时候预后较差。需要进一步的研究来确定与艾滋病毒感染者胰腺癌发展相关的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JAIDS Journal of Acquired Immune Deficiency Syndromes 医学-传染病学

CiteScore

5.80

自引率

5.60%

发文量

490

审稿时长

3-6 weeks

期刊介绍： JAIDS: Journal of Acquired Immune Deficiency Syndromes seeks to end the HIV epidemic by presenting important new science across all disciplines that advance our understanding of the biology, treatment and prevention of HIV infection worldwide. JAIDS: Journal of Acquired Immune Deficiency Syndromes is the trusted, interdisciplinary resource for HIV- and AIDS-related information with a strong focus on basic and translational science, clinical science, and epidemiology and prevention. Co-edited by the foremost leaders in clinical virology, molecular biology, and epidemiology, JAIDS publishes vital information on the advances in diagnosis and treatment of HIV infections, as well as the latest research in the development of therapeutics and vaccine approaches. This ground-breaking journal brings together rigorously peer-reviewed articles, reviews of current research, results of clinical trials, and epidemiologic reports from around the world.