Immunological Factors and Macronutrient Content in Human Milk From Women With Subclinical Mastitis.

IF 2.1 4区 医学 Q2 NURSING Journal of Human Lactation Pub Date : 2024-12-20 DOI:10.1177/08903344241297585
Mizuho Ito, Miori Tanaka, Midori Date, Kumiko Miura, Katsumi Mizuno
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Abstract

Background: Subclinical mastitis is an asymptomatic inflammatory condition of the lactating mammary glands possibly associated with premature interruption of breastfeeding and poor weight gain in infants. However, data on human milk composition in mothers with subclinical mastitis are limited and inconsistent. Although human milk from donors with subclinical mastitis may be used after pasteurization if it meets the criteria, whether the composition is suitable for donor human milk remains unknown.

Research aims: This study assessed the human milk composition of participants with subclinical mastitis and verified the safety of donor human milk, including that from mothers with subclinical mastitis.

Methods: This cross-sectional survey included 106 milk samples collected between March 2022 and January 2023. Subclinical mastitis status was assessed using the sodium-potassium ratio, which was measured using an ion-selective electrode. The concentrations of lactoferrin and secretory Immunoglobulin A were analyzed using an enzyme-linked immunosorbent assay. True protein, fat, carbohydrate, and energy levels were analyzed using a mid-infrared transmission spectroscopy.

Results: In human milk from the subclinical mastitis group, lactoferrin and true protein concentrations were significantly increased compared to those without subclinical mastitis. A positive correlation was observed between lactoferrin and secretory Immunoglobulin A levels.

Conclusions: Increased immunological substances and protein concentrations in human milk are similar to those observed in clinical mastitis, indicating an inflammatory response in the body, even in asymptomatic individuals. Immunological substances and proteins are beneficial for preterm infants. Therefore, human milk from mothers with subclinical mastitis is suitable for use by milk banks.

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来源期刊
Journal of Human Lactation
Journal of Human Lactation 医学-妇产科学
CiteScore
5.00
自引率
11.50%
发文量
100
审稿时长
6-12 weeks
期刊介绍: Committed to the promotion of diversity and equity in all our policies and practices, our aims are: To provide our readers and the international communities of clinicians, educators and scholars working in the field of lactation with current and quality-based evidence, from a broad array of disciplines, including the medical sciences, basic sciences, social sciences and the humanities. To provide student and novice researchers, as well as, researchers whose native language is not English, with expert editorial guidance while preparing their work for publication in JHL. In each issue, the Journal of Human Lactation publishes original research, original theoretical and conceptual articles, discussions of policy and practice issues, and the following special features: Advocacy: A column that discusses a ‘hot’ topic in lactation advocacy About Research: A column focused on an in-depth discussion of a different research topic each issue Lactation Newsmakers: An interview with a widely-recognized outstanding expert in the field from around the globe Research Commentary: A brief discussion of the issues raised in a specific research article published in the current issue Book review(s): Reviews written by content experts about relevant new publications International News Briefs: From major international lactation organizations.
期刊最新文献
Immunological Factors and Macronutrient Content in Human Milk From Women With Subclinical Mastitis. Considerations When Measuring Exclusive Breastfeeding. Bridging the Gap Between Lactation Care and Research in Human Lactation. Utilizing Lactation Acuity to Improve Lactation Services in a U.S. Hospital. Breastfeeding Intentions, Attitudes, and Knowledge Among Medical Students in Croatia.
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