Gastrointestinal Dysfunction Bears on the Clinical-Biological Profile of Parkinson's Disease.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY Movement Disorders Clinical Practice Pub Date : 2025-04-01 Epub Date: 2024-12-20 DOI:10.1002/mdc3.14319

Jacopo Bissacco, Roberta Bovenzi, Matteo Conti, Clara Simonetta, Davide Mascioli, Rocco Cerroni, Giulia Maria Sancesario, Piergiorgio Grillo, Mariangela Pierantozzi, Alessandro Stefani, Nicola Biagio Mercuri, Marta Camacho, Tommaso Schirinzi

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Abstract

Background: Gastrointestinal dysfunction (GID) accompanies any phase of Parkinson's disease (PD), underlying differential clinical-pathological trajectories.

Objective: To investigate associations between GID and peripheral immune or neurodegeneration-related markers in PD.

Methods: One-hundred-and-fourteen patients (n = 55 de novo, DN; n = 59 middle-advanced, MA) completed the Gastrointestinal Dysfunction Scale for PD (GIDS-PD), and other motor and non-motor scales; paired measurement of amyloid-β42, amyloid-β42β/β40, total-tau, phosphorylated-181-tau, total α-synuclein CSF levels, albumin ratio, and peripheral blood cell count were collected. Group and correlation analyses were performed.

Results: MA patients had greater GID than DN. GIDS-PD scores directly correlated with MDS-UPDRS-III and non-motor scores in both groups, although more in DN. GIDS-PD scores were directly associated with α-synuclein and inversely with lymphocytes only in DN; conversely, they were positively associated with tau proteins and albumin ratio, and negatively with amyloid-β-peptides in both groups.

Conclusions: The burden of GID increases along the PD course with associated stage-specific clinical-biological patterns.

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胃肠道功能障碍对帕金森病临床生物特征的影响。

背景：胃肠道功能障碍（GID）伴随帕金森病（PD）的任何阶段，潜在的不同临床病理轨迹。目的：探讨GID与PD患者周围免疫或神经退行性相关标志物的关系。方法：114例患者(n = 55例新发DN；n = 59例中晚期，MA)完成胃肠功能障碍量表（gads -PD）及其他运动和非运动量表；配对测定淀粉样蛋白-β42、淀粉样蛋白-β42β/β40、总tau蛋白、磷酸化-181-tau蛋白、总α-突触核蛋白CSF水平、白蛋白比率和外周血细胞计数。进行分组分析和相关分析。结果：MA患者GID大于DN。GIDS-PD评分与MDS-UPDRS-III和非运动评分直接相关，但在DN中更多。只有DN患者GIDS-PD评分与α-突触核蛋白呈正相关，与淋巴细胞呈负相关；相反，它们与tau蛋白和白蛋白比率呈正相关，与淀粉样蛋白-β-肽负相关。结论：GID的负担随着PD病程的增加而增加，并伴有相关的分期特异性临床生物学模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)