Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY Movement Disorders Clinical Practice Pub Date : 2025-03-01 Epub Date: 2024-12-20 DOI:10.1002/mdc3.14314

Tiziana De Santis, Antoniangela Cocco, Paolo Castiglioni, Maurizio Ferrarin, Rossana Mineri, Emanuela Morenghi, Micol Avenali, Alberto Albanese

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Abstract

Background: The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive.

Objectives: To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease.

Methods: These assessments were performed: cardiovascular autonomic tests, analysis of heart rate and blood pressure variability, cardiac noradrenergic imaging. The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA-AUT questionnaire.

Results: Compared to the I-PD cohort, GBA-PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA-PD while sympathetic indexes and the degree of cardiac sympathetic binding were comparable in the two groups. Heart rate variability indexes also revealed lower vagal modulation in the GBA-PD group.

Conclusions: The cardiovascular autonomic profile in GBA PD is characterized by a prominent cardiovagal dysfunction compared to I-PD.

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GBA1相关帕金森病患者的副交感神经功能普遍失调

背景：交感神经和副交感神经自主神经分支在携带GBA1基因变异（GBA-PD）的帕金森病患者中所起的作用尚不清楚。目的：探讨早中期GBA-PD和I-PD患者的心血管自主神经功能。方法：进行这些评估：心血管自主功能测试，心率和血压变异性分析，心脏去甲肾上腺素能成像。采用SCOPA-AUT问卷比较评估自主神经症状的发生频率和严重程度。结果：与I-PD队列相比，GBA-PD患者表现出更大的自主神经症状负担。自主神经测试显示，GBA-PD的副交感神经评分较差，而两组的交感神经指数和心脏交感神经结合程度相当。心率变异性指数也显示GBA-PD组迷走神经调节较低。结论：与I-PD相比，大湾区PD的心血管自主神经特征以明显的心血管功能障碍为特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)