Inflammatory protein levels in asthmatic bronchitis: A study in the Duhok population, Iraq.

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins & other lipid mediators Pub Date : 2024-12-17 DOI:10.1016/j.prostaglandins.2024.106942

Omar A M Al-Habib, Hamdia Yousif Issa, Taner Dastan, Sevgi Durna Dastan, Ali A Ramadhan, Zeliha Selamoglu

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Abstract

Objectives: This study aims to determine the levels of TNF-α, IGF-1, IL-6, and IL-10 protein in blood samples and their potential link to bronchitis-asthma diseases in the Iraq Duhok population, highlighting the prevalence of these long-term inflammatory diseases.

Methods: Sixty blood samples were used and separated into patients (n = 43) and control (n = 17) groups. Serum samples were separated for each individual. Elisa method was used in terms of 4 different proteins investigated in blood samples with the manufacturer's instruction brand kits.

Results: This study evaluated TNF-α, IGF-1, IL-6, and IL-10 protein levels in blood samples from asthmatic bronchitis patients in Duhok. Although these levels were elevated compared to controls, the differences were not statistically significant.

Conclusion: The differences thought to be related to the bronchitis-asthma diseases could not be demonstrated between the patient and control groups in Iraq Duhok population. Future research should explore larger sample sizes and stratified patient groups to identify potential biomarkers.

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研究目的本研究旨在确定血液样本中 TNF-α、IGF-1、IL-6 和 IL-10 蛋白的水平及其与伊拉克杜霍克人口中支气管炎-哮喘疾病的潜在联系，突出这些长期炎症性疾病的发病率：使用了 60 份血液样本，并将其分为患者组（样本数=43）和对照组（样本数=17）。每个人的血清样本均已分离。结果：该研究评估了 TNF-α、TNF-α-1、TNF-α-2、TNF-α-3、TNF-α-4 和 TNF-α-5：本研究评估了杜霍克哮喘性支气管炎患者血液样本中的 TNF-α、IGF-1、IL-6 和 IL-10 蛋白水平。虽然这些水平与对照组相比有所升高，但差异并无统计学意义：结论：认为与支气管炎-哮喘疾病相关的差异在伊拉克杜霍克人群中的患者组和对照组之间未能得到证实。未来的研究应探索更大的样本量和分层患者群体，以确定潜在的生物标志物。

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.