Meta analysis of the influencing factors of sarcopenia in patients with Crohn's disease

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL American Journal of the Medical Sciences Pub Date : 2024-12-17 DOI:10.1016/j.amjms.2024.12.010

Zhihui Yu MNS , Qing Liu MNS , Yan Chen BSN , Danlei Chen MNS , Ting Pan MNS , Fang Kong BSN

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Abstract

Objective

To conduct a meta-analysis of the factors influencing sarcopenia in patients with Crohn's disease and provide evidence-based findings for early clinical detection and prevention.

Methods

The study was registered on PROSPERO(CRD42023470300). A systematic review was performed on literature pertaining to sarcopenia in patients with Crohn's disease utilizing eight Chinese and English databases, which consist of CNKI, Wanfang, VIP, CBM, PubMed, Web of Science, Embase, and The Cochrane Library. The search was carried out from the inception of each database until October 8, 2023. Data analysis was carried out using the Stata 14.0 software.

Results

A total of 603 Chinese and English literature sources were reviewed, and following the application of the inclusion and exclusion criteria, 9 articles were selected. These 9 articles take into account a total of 22 factors that may influence the occurrence of sarcopenia in Crohn's disease patients. The results of the meta-analysis demonstrate that gender (OR=5.49, 95 % CI [2.08,14.51]), BMI (OR=0.77, 95 % CI [0.62,0.95]), age (OR=1.03, 95 % CI [1.01,1.05]), and low albumin levels (OR=1.08, 95 % CI [1.01,1.15]) have significant impacts on the emergence of sarcopenia in patients with Crohn's disease.

Conclusions

The occurrence of sarcopenia in Crohn's disease patients is mainly influenced by gender, BMI, age, and low albumin levels. Additional factors that may influence the condition require further research to verify.

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克罗恩病患者肌肉减少症影响因素的Meta分析。

目的：对克罗恩病患者肌肉减少症的影响因素进行荟萃分析，并提出循证结果，以帮助临床早期发现和预防。方法：该研究在PROSPERO注册（CRD42023470300）。采用中国知网、万方、维普、中国生物医学、PubMed、Web of Science、Embase、Cochrane图书馆等8个中英文数据库对克罗恩病患者肌肉减少症相关文献进行系统综述。搜索从每个数据库的开始到2023年10月8日进行。采用Stata 14.0软件进行数据分析。结果：共查阅中英文文献603篇，按照纳入和排除标准，筛选出9篇。这9篇文章总共考虑了22个可能影响克罗恩病患者肌肉减少症发生的因素。meta分析结果显示，性别（OR=5.49, 95% CI[2.08,14.51]）、BMI （OR=0.77, 95% CI[0.62,0.95]）、年龄（OR=1.03, 95% CI[1.01,1.05]）和低白蛋白水平（OR=1.08, 95% CI[1.01,1.15]）对克罗恩病患者肌肉减少症的发生有显著影响。结论：克罗恩病患者肌肉减少症的发生主要受性别、BMI、年龄、低白蛋白水平的影响。可能影响病情的其他因素需要进一步的研究来验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of the Medical Sciences 医学-医学：内科

CiteScore

4.40

自引率

0.00%

发文量

303

审稿时长

1.5 months

期刊介绍： The American Journal of The Medical Sciences (AJMS), founded in 1820, is the 2nd oldest medical journal in the United States. The AJMS is the official journal of the Southern Society for Clinical Investigation (SSCI). The SSCI is dedicated to the advancement of medical research and the exchange of knowledge, information and ideas. Its members are committed to mentoring future generations of medical investigators and promoting careers in academic medicine. The AJMS publishes, on a monthly basis, peer-reviewed articles in the field of internal medicine and its subspecialties, which include: Original clinical and basic science investigations Review articles Online Images in the Medical Sciences Special Features Include: Patient-Centered Focused Reviews History of Medicine The Science of Medical Education.