Highly Efficient Heteronuclear Polarization Transfer by Dipolar-Echo Edited R-Symmetry Sequences in Solid-State NMR

IF 7.6 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical Science Pub Date : 2024-12-21 DOI:10.1039/d4sc07965e
Guangjin Hou, Lixin Liang, Kuizhi Chen
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Abstract

In solid-state NMR, the dipolar-based heteronuclear polarization transfer has been extensively used for sensitivity enhancement and multidimensional correlations, but its efficiency often suffers from undesired spin interactions and hardware limitations. Herein, we propose a novel dipolar-echo edited R-symmetry (DEER) sequence, which is further incorporated into the INEPT-type scheme, dubbed DEER-INEPT, for achieving high efficient heteronuclear polarization transfer. Numerical simulations and NMR experiments demonstrate that DEER-INEPT offers significantly improved robustness, enabling efficient polarization transfer across a wide range of MAS conditions, from slow to ultrafast rates, outperforming existing methods. Its high efficiency leads to noticeably enhanced sensitivity in both 1H→X and X→1H transfers, applicable to both spin-1/2 and spin-half-integer quadrupolar nuclei. DEER-INEPT is expected to be widely used in various systems, offering advantages in both sensitivity enhancement and structural analysis.
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来源期刊
Chemical Science
Chemical Science CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
14.40
自引率
4.80%
发文量
1352
审稿时长
2.1 months
期刊介绍: Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.
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