Catalyst-Free, Radical Tri- and Difluoromethylation of Isocyanides and N-Arylacrylamides Using Rotating Magnetic Field and Metal Rods

Abstract

The pursuit of sustainable and environmentally benign synthetic methods continues to challenge organic chemists. Herein, we introduce a magnetoredox system for tri- and difluoromethylation of isocyanides and N-arylacrylamides using a rotating magnetic field and steel rods. This magnetoredox approach enables facile synthesis of functionalized phenanthridines and oxindoles without the need for catalysts and additives under mild conditions. Such a system potentially represents an attractive strategy for selective formation of bonds through multifaceted regulation of magnetic intensity, rotating frequency, and rod size.