AMPK down-regulating Beclin-1 in prostate cancer patients with bone metastasis: An observational study.

IF 1.3 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Medicine Pub Date : 2024-12-20 DOI:10.1097/MD.0000000000041024
Jiaxing Chen, Lingyun Hu, Wangguang Zhou, Chaoyang Wang, Xuewu Zhou
{"title":"AMPK down-regulating Beclin-1 in prostate cancer patients with bone metastasis: An observational study.","authors":"Jiaxing Chen, Lingyun Hu, Wangguang Zhou, Chaoyang Wang, Xuewu Zhou","doi":"10.1097/MD.0000000000041024","DOIUrl":null,"url":null,"abstract":"<p><p>Bone metastasis is frequently seen in patients, particularly those with prostate cancer, showing a higher hazard that deteriorates the quality of life of patients, leading to poor prognosis, which eventually causes significant mortality in prostate cancer patients. The present study investigated the mechanism of prostate cancer with bone metastasis by utilizing prostate specimens from patients. A total of 418 patients were initially enrolled for clinical analysis, including age, prostate-specific antigen (PSA) levels, body mass index (BMI), prostate magnetic resonance imaging (MRI), and bone MRI, while pathological analysis included grade group and carcinoma of the prostate. Patients were divided into a prostate cancer with bone metastasis group (group 1, prostate cancer patients) and benign prostate patient group (group 2, control group) and underwent subsequent immunohistochemical (IHC) detection. Expression of AMPK/Beclin-1 signaling pathways was analyzed through immunohistochemistry. Finally, 46 patients with prostate cancer bone metastasis (prostate cancer patients) and 61 patients with benign prostate (control group) met the inclusion criteria. We examined the expression levels of Beclin-1 and AMPK in human prostate tissues by IHC and found that Beclin-1 levels were negatively correlated with AMPK in prostate cancer with bone metastasis (P < .05). The results of this study suggest that AMPK-Beclin-1 significantly reduces prostate cancer metastasis to the bone in human tissues.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"103 51","pages":"e41024"},"PeriodicalIF":1.3000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666198/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MD.0000000000041024","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Bone metastasis is frequently seen in patients, particularly those with prostate cancer, showing a higher hazard that deteriorates the quality of life of patients, leading to poor prognosis, which eventually causes significant mortality in prostate cancer patients. The present study investigated the mechanism of prostate cancer with bone metastasis by utilizing prostate specimens from patients. A total of 418 patients were initially enrolled for clinical analysis, including age, prostate-specific antigen (PSA) levels, body mass index (BMI), prostate magnetic resonance imaging (MRI), and bone MRI, while pathological analysis included grade group and carcinoma of the prostate. Patients were divided into a prostate cancer with bone metastasis group (group 1, prostate cancer patients) and benign prostate patient group (group 2, control group) and underwent subsequent immunohistochemical (IHC) detection. Expression of AMPK/Beclin-1 signaling pathways was analyzed through immunohistochemistry. Finally, 46 patients with prostate cancer bone metastasis (prostate cancer patients) and 61 patients with benign prostate (control group) met the inclusion criteria. We examined the expression levels of Beclin-1 and AMPK in human prostate tissues by IHC and found that Beclin-1 levels were negatively correlated with AMPK in prostate cancer with bone metastasis (P < .05). The results of this study suggest that AMPK-Beclin-1 significantly reduces prostate cancer metastasis to the bone in human tissues.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
骨转移经常见于前列腺癌患者,尤其是前列腺癌患者,其危害性较大,会恶化患者的生活质量,导致预后不良,最终导致前列腺癌患者大量死亡。本研究利用患者的前列腺标本,对前列腺癌骨转移的机制进行了研究。研究最初共纳入 418 名患者,对其进行临床分析,包括年龄、前列腺特异性抗原(PSA)水平、体重指数(BMI)、前列腺磁共振成像(MRI)和骨磁共振成像,病理分析包括前列腺分级组和前列腺癌。患者被分为前列腺癌骨转移组(第1组,前列腺癌患者)和良性前列腺患者组(第2组,对照组),并接受免疫组化(IHC)检测。通过免疫组化分析 AMPK/Beclin-1 信号通路的表达。最后,46 名前列腺癌骨转移患者(前列腺癌患者)和 61 名良性前列腺患者(对照组)符合纳入标准。我们通过 IHC 检测了人类前列腺组织中 Beclin-1 和 AMPK 的表达水平,发现在骨转移的前列腺癌患者中,Beclin-1 水平与 AMPK 呈负相关(P<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Medicine
Medicine 医学-医学:内科
CiteScore
2.80
自引率
0.00%
发文量
4342
审稿时长
>12 weeks
期刊介绍: Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.
期刊最新文献
Acupuncture and electroacupuncture for cyclic vomiting syndrome with tachygastria in an adult: A case report. Advancements in the application of precision nursing model on hemodialysis for diabetic nephropathy: A review. Advances in theories and models of cardiac rehabilitation after acute myocardial infarction: A narrative review. AMPK down-regulating Beclin-1 in prostate cancer patients with bone metastasis: An observational study. A case of posterior urethral valve diagnosed by ultrasound in antenatal and pathology: A case report.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1