An integrated wearable microfluidic biosensor for simultaneous detection of multiple biomarkers in sweat.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-16 DOI:10.1016/j.talanta.2024.127404

Yong Zhang, Xin Zeng, Cuncun Wang, Yiyi Liu, Changpeng Jin, Jian Chen, Jingzhou Hou, Danqun Huo, Changjun Hou

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Abstract

Simultaneous detection of biomarkers in sweat is crucial for comprehensive health assessment and personalized monitoring. However, the low sweat secretion rate and low metabolite concentrations present challenges for developing non-invasive wearable sensors. This study aims to develop a flexible wearable biosensor for simultaneous detection of low-concentration biomarkers in sweat, enabling comprehensive health assessment. This study synthesized an innovative bimetallic tungstate Ag@Ag₂WO₄ and evaluated its performance for detecting uric acid (UA, 10-1000 μM), dopamine (DA, 3-500 μM), and tyrosine (Tyr, 5-1000 μM). The detection limits (LODs) for DA, UA, and Tyr sensors were 3.10 μM, 8.47 μM, and 4.17 μM, respectively, with relative standard deviations (RSDs) of 4.76 %, 2.66 %, and 3.51 %, respectively. Additionally, this study designed a hydrophilic microfluidic collection system inspired by bamboo leaf structures to enhance sweat collection efficiency. Validation studies demonstrated that the wearable biosensor effectively detects UA and TA in the sweat of volunteers. We believe this research could contribute to advancing personalized healthcare by improving the convenience and effectiveness of health monitoring technologies.

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一种集成的可穿戴微流体生物传感器，用于同时检测汗液中的多种生物标志物。

同时检测汗液中的生物标志物对于全面的健康评估和个性化监测至关重要。然而，低汗液分泌率和低代谢物浓度为开发无创可穿戴传感器提出了挑战。本研究旨在开发一种灵活的可穿戴生物传感器，用于同时检测汗液中的低浓度生物标志物，从而实现全面的健康评估。本研究合成了一种新型双金属钨酸盐Ag@Ag2WO4，并对其检测尿酸（UA, 10-1000 μM）、多巴胺（DA, 3-500 μM）和酪氨酸（Tyr, 5-1000 μM）的性能进行了评价。DA、UA和Tyr传感器的检出限分别为3.10 μM、8.47 μM和4.17 μM，相对标准偏差（rsd）分别为4.76%、2.66%和3.51%。此外，本研究还设计了一种以竹叶结构为灵感的亲水微流控收集系统，以提高汗液的收集效率。验证研究表明，可穿戴生物传感器可以有效地检测志愿者汗液中的UA和TA。我们相信这项研究可以通过提高健康监测技术的便利性和有效性来促进个性化医疗保健。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.