Religion, spirituality, and DNA methylation in HPA-axis genes among Hispanic/Latino adults.

IF 3 4区医学 Q2 GENETICS & HEREDITY Epigenomics Pub Date : 2025-02-01 Epub Date: 2024-12-20 DOI:10.1080/17501911.2024.2442293

Jenny Zhen-Duan, Katia M Canenguez, Anna E Wilson, Yue Gu, Harshitha G Valluri, Alejandra D Chavez, M Austin Argentieri, Anna Boonin Schachter, Haotian Wu, Andrea A Baccarelli, Martha L Daviglus, Sylvia Wassertheil-Smoller, Erica T Warner, Alexandra E Shields

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Abstract

Aim: Investigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts.

Methods: We assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status.

Results: Among individuals with the FKBP5 CC genotype, increased spirituality scores were associated with significantly lower methylation levels among immigrants, compared to US-born participants. Organizational religiosity (e.g. service attendance) was associated with increased FKBP5 (CC genotype) methylation among immigrants.

Conclusion: R&S may influence HPA-axis functioning differently based on nativity status; a finding that could offer insight into mechanisms leading to health disparities.

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西班牙/拉丁裔成人中hpa轴基因的宗教、灵性和DNA甲基化。

目的：研究来自西班牙裔社区健康研究/拉丁裔研究队列的992名成年人的宗教和灵性（R&S）与四个hpa轴基因（即14个CpG位点）的DNA甲基化之间的关系。方法：我们评估了1)R&S测量与总体甲基化平均百分比之间的关系，并根据出生状况（美国出生或移民）分层；2)R&S和甲基化之间的相互作用是否因出生状况而异。结果：在FKBP5 CC基因型的个体中，与美国出生的参与者相比，移民中灵性得分的增加与甲基化水平的显著降低相关。在移民中，有组织的宗教信仰（如参加礼拜）与FKBP5 （CC基因型）甲基化增加有关。结论：出生状态不同，R&S对hpa轴功能的影响不同；这一发现可以深入了解导致健康差异的机制。

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.