Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study.

IF 5.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Health Pub Date : 2024-12-20 DOI:10.1186/s12940-024-01150-7
Xuehua Ruan, Wenyuan Shang, Jieru Lu, Zhuoyan Li, Jing Yang, Jinping Cheng, Yurong Wu, Kun Sun, Jing Sun
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引用次数: 0

Abstract

Background: Congenital heart disease (CHD) is a common birth defect. Our previous studies suggest that indoor air pollution, especially total volatile organic compounds (TVOCs), may increase fetal CHD risk, whereas vitamin and folic acid (FA) supplements in early pregnancy might offer protection against CHD. However, limited research has explored whether FA or multivitamin supplementation can mitigate the effects of TVOCs exposure on CHD.

Methods: We conducted a case-control study to investigate the association between maternal nutrient supplementation, household indoor air pollutant exposure during pregnancy, and CHD in offspring. Pregnant women with 22-30 gestational weeks were recruited from two hospitals in East China between January 2016 and March 2022. A comprehensive approach was used, incorporating questionnaires to collect nutrient supplement information, blood sample analysis to detect serum folate, vitamin B12, and homocysteine (HCY) concentrations, and field investigations to assess indoor benzene, toluene, xylene, formaldehyde, and TVOCs exposures. Logistic regression analysis was performed to identify CHD risk factors, and stratified analysis was used to evaluate the combined effects of nutrient supplementation and TVOCs on CHD.

Results: The study included 53 cases and 77 controls. Logistic regression analysis identified high maternal serum HCY (> 6.125 µmol/L) and high household TVOCs exposure (> 0.0165 mg/m³) as risk factors for CHD in offspring, with adjusted odds ratios of 2.98 (95% CI: 1.31-6.36) and 9.23 (95% CI: 3.78-22.53), respectively. Regular multivitamin supplementation mitigated the risk of high TVOCs exposure on fetal CHD, while the adverse effect of high serum HCY-related CHD risk was attenuated in the group with regular FA supplementation.

Conclusion: Exposure to high indoor TVOCs concentrations increases the risk of fetal CHD. Regular multivitamin supplementation may reduce the adverse effects of high TVOCs exposure on fetal CHD.

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来源期刊
Environmental Health
Environmental Health 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
10.10
自引率
1.70%
发文量
115
审稿时长
3.0 months
期刊介绍: Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.
期刊最新文献
Air pollution is linked to cognitive decline independent of hypersensitive C-reactive protein: insights from middle-aged and older Chinese. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Correction: Epidemiologic and clinical features of cyanobacteria harmful algal bloom exposures reported to the National Poison Data System, United States, 2010-2022: a descriptive analysis. Per- and polyfluoroalkyl substances, apolipoproteins and the risk of coronary heart disease in US men and women. Association between acute exacerbation of chronic obstructive pulmonary disease and short-term exposure to ambient air pollutants in France.
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