Cost-Effectiveness Analyses of Bone Morphogenetic Protein 2 (rhBMP-2) in Spinal Fusion: A Systematic Review.

IF 2.6 3区医学 Q2 CLINICAL NEUROLOGY Global Spine Journal Pub Date : 2024-12-20 DOI:10.1177/21925682241310864

Ravi S Nunna, Maxwell D Gruber, Sasidhar Karuparti, Zachary Taylor, Sabrina Genovese, Fareed Jumah, Periklis Godolias, Zachary Tataryn, Douglas Hollern, Rod Oskouian, Jens R Chapman

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引用次数: 0

Abstract

Study design: Systematic Review Study.

Objectives: The objective of this study is to assess the cost-effectiveness and cost-utility of rhBMP-2 in spine surgeries.

Methods: PubMed, MEDLINE, OVID and CENTRAL (Cochrane Central Register of Controlled Trials) databases were systematically searched for studies reporting the use of rhBMP-2 for spinal procedures in comparison to autograft and/or allograft and alternative graft materials under consideration of cost-effectiveness, cost-benefit, cost minimization, and/or cost-utility analysis. Relevant data points were extracted and compiled. The standardization of the selected studies was graded using the CHEERS criteria.

Results: Of the 88 eligible publications, 17 met the inclusion criteria. Overall, 8 studies showed a favorable cost-analysis profile. Three studies performed cost-consequence analyses, none of which reported positive findings. Among 7 cost-utility analyses and 7 cost-effectiveness analyses, 3 and 5, respectively, reported a likely benefit to the usage of rhBMP-2. The CHEERS scores for the included studies ranged from 15 to 23 out of 24 points, with a median score of 19.

Conclusions: There is no consensus regarding the cost-effectiveness or cost-utility of rhBMP-2 in spinal fusion. rhBMP-2 may function as a cost-effective adjunct in spinal fusion surgeries in select cases.

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骨形态发生蛋白2 （rhBMP-2）在脊柱融合术中的成本-效果分析：系统综述。

研究设计：系统评价研究。目的：本研究的目的是评估rhBMP-2在脊柱手术中的成本-效果和成本-效用。方法：系统检索PubMed、MEDLINE、OVID和CENTRAL （Cochrane CENTRAL Register of Controlled Trials）数据库，根据成本-效果、成本-收益、成本最小化和/或成本-效用分析，与自体移植物和/或同种异体移植物和替代移植物材料相比，报道在脊柱手术中使用rhBMP-2的研究。提取并整理相关数据点。所选研究的标准化使用CHEERS标准进行分级。结果：88篇入选文献中，17篇符合纳入标准。总的来说，8项研究显示了有利的成本分析概况。三项研究进行了成本-后果分析，没有一项研究报告了积极的结果。在7个成本效用分析和7个成本效益分析中，分别有3个和5个报告了使用rhBMP-2可能带来的好处。所纳入研究的CHEERS得分为15 - 23分（总分24分），中位数为19分。结论：关于rhBMP-2在脊柱融合术中的成本-效果或成本-效用尚无共识。在某些病例中，rhBMP-2可能作为一种经济有效的辅助手段在脊柱融合手术中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Global Spine Journal Medicine-Surgery

CiteScore

6.20

自引率

8.30%

发文量

278

审稿时长

8 weeks

期刊介绍： Global Spine Journal (GSJ) is the official scientific publication of AOSpine. A peer-reviewed, open access journal, devoted to the study and treatment of spinal disorders, including diagnosis, operative and non-operative treatment options, surgical techniques, and emerging research and clinical developments.GSJ is indexed in PubMedCentral, SCOPUS, and Emerging Sources Citation Index (ESCI).