Site-Selective Electrophilic Trifluoromethylthiolation for the Synthesis of C5- or C7-SCF3-Substituted Indolines

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2024-12-23 DOI:10.1021/acs.orglett.4c04500

Xiaolong Wang, Yan Fu, Zhenshan Guo, Aijun Lin, Qingzhong Jia, Chunhua Han

引用次数: 0

Abstract

We report herein an efficient and site-selective electrophilic trifluoromethylthiolation of indolines. In the absence of any catalyst or additive, C5-selective trifluoromethylthiolation could proceed at room temperature. With palladium used as the catalyst, the selectivity was reversed completely, giving C7-selecive trifluoromethylthiolated products. This reaction features good functional group tolerance, simple operation, mild conditions, and scale-up application. The potential utilities of the products were shown by further transformations.

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位置选择性亲电性三氟甲基硫基化合成C5-或c7 - scf3取代吲哚

我们在此报道了吲哚类药物的高效和位点选择性的亲电三氟甲基硫基化。在没有任何催化剂或添加剂的情况下，c5选择性三氟甲基硫基化可以在室温下进行。以钯为催化剂时，选择性完全逆转，得到具有c7选择性的三氟甲基硫化产物。该反应具有官能团耐受性好、操作简单、条件温和、可大规模应用等特点。进一步的转换显示了产品的潜在效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.

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