Predictive value of NT-proBNP for major adverse cardiovascular events within a 6-month period in patients with acute coronary syndrome.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Irish Journal of Medical Science Pub Date : 2024-12-23 DOI:10.1007/s11845-024-03849-5

Ozlem Canan Ozbaltan, Sumeyye Cakmak, Ozgur Sogut, Adem Az, Hasan Ogur

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Abstract

Background: The role of NT-proBNP as a cardiac biomarker for predicting short-term major adverse cardiovascular events (MACEs) in acute coronary syndrome (ACS) remains unclear.

Aims: This study investigated the utility of the NT-proBNP level for predicting MACEs within a 6-month period in patients with ACS.

Methods: This prospective study included 241 consecutively enrolled adults with ACS between September 2023 and February 2024. Demographic data, clinical characteristics, GRACE score, and high-sensitivity cardiac troponin T (hs-cTnT) and NT-proBNP levels were compared between patients who were MACE-positive vs. MACE-negative within a 6-month period.

Results: The overall mortality rate was 8.7%, and the incidence of MACEs was 43.2%. The mean serum levels of hs-cTnT and NT-proBNP were significantly higher in the MACE-positive than in the MACE-negative group. Age, concomitant coronary artery disease, NT-proBNP, and GRACE score were independent predictors of MACEs in patients with ACS. An NT-proBNP level of 250 pg/mL had a sensitivity of 73.1% and a specificity of 88.3% for predicting MACEs, with an area under the curve of 0.847. The estimated risk of MACEs was 70% and 90% for NT-proBNP values of 600 pg/mL and 900 pg/mL, respectively.

Conclusion: The NT-proBNP level measured at ED admission was strongly associated with short-term MACEs in patients with all ACS subtypes and was an important prognostic biomarker. Therefore, combining the NT-proBNP level with the GRACE score in ACS patients may provide significant benefits in terms of predicting MACEs and obtaining a more accurate risk stratification.

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NT-proBNP对急性冠脉综合征患者6个月内主要不良心血管事件的预测价值

背景：NT-proBNP作为预测急性冠脉综合征（ACS）患者短期主要不良心血管事件（mace）的心脏生物标志物的作用尚不清楚。目的：本研究探讨了NT-proBNP水平在ACS患者6个月内预测mace的效用。方法：这项前瞻性研究纳入了241名在2023年9月至2024年2月期间连续入组的ACS成人患者。在6个月内比较mace阳性和mace阴性患者的人口学数据、临床特征、GRACE评分和高敏心肌肌钙蛋白T （hs-cTnT）和NT-proBNP水平。结果：总死亡率为8.7%，mace发生率为43.2%。mace阳性组血清hs-cTnT和NT-proBNP平均水平明显高于mace阴性组。年龄、合并冠状动脉疾病、NT-proBNP和GRACE评分是ACS患者mace的独立预测因子。NT-proBNP水平为250 pg/mL时，预测mace的敏感性为73.1%，特异性为88.3%，曲线下面积为0.847。NT-proBNP值分别为600 pg/mL和900 pg/mL时，mace的估计风险分别为70%和90%。结论：ED入院时测量的NT-proBNP水平与所有ACS亚型患者的短期mes密切相关，是一个重要的预后生物标志物。因此，将NT-proBNP水平与ACS患者的GRACE评分相结合可能在预测mace和获得更准确的风险分层方面提供显著的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.