Prevalence of antihypertensive medication adherence and associated factors in India: A systematic review and meta-analysis.

IF 1.2 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Hipertension y Riesgo Vascular Pub Date : 2024-12-21 DOI:10.1016/j.hipert.2024.11.005

B Pal, A Dutta, V Chaudhary, S Kumari, S Meenakshi, K Murti

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Abstract

Background: Non-adherence to antihypertensive medication is a key factor contributing to uncontrolled blood pressure and the subsequent complications of hypertension. Despite its importance, there is a lack of data regarding the prevalence of and factors associated with non-adherence to medication among individuals with hypertension in India. This review aimed to assess medication adherence rates among hypertensive patients in India and identify the factors influencing non-adherence.

Methods: A comprehensive search was conducted across PubMed, Scopus, Embase, and Google Scholar. Studies reporting medication adherence/non-adherence to antihypertensive medications in India, using the Morisky Medication Adherence Scale (MMAS), with publication dates up to July 2023, were included.

Results: Twelve studies were included, involving a total of 3164 participants. The pooled rate of medication adherence to antihypertensive medications in India was determined to be 15.8% (95% CI: 4.4; 43.4). The important factors associated with non-adherence included higher age, medication regimen complexity, low socioeconomic status, low education levels, uncontrolled blood pressure, and comorbidities.

Conclusions: The adherence rate to antihypertensive medication was observed to be quite low. Therefore, it is imperative to enhance the rate of medication adherence among individuals with hypertension in order to attain effective blood pressure control and reduce the burden of non-communicable diseases.

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印度抗高血压药物依从性患病率及相关因素：系统回顾和荟萃分析

背景：不坚持降压药物治疗是导致血压失控和高血压并发症的关键因素。尽管它很重要，但缺乏关于印度高血压患者不坚持服药的患病率和相关因素的数据。本综述旨在评估印度高血压患者的药物依从率，并确定影响不依从性的因素。方法：在PubMed、Scopus、Embase和谷歌Scholar中进行综合检索。纳入了使用Morisky药物依从性量表（MMAS）报告印度降压药依从性/不依从性的研究，出版日期截止到2023年7月。结果：纳入12项研究，共涉及3164名受试者。印度抗高血压药物的总依从率为15.8% (95% CI: 4.4；43.4)。与不依从性相关的重要因素包括年龄较大、用药方案复杂、低社会经济地位、低教育水平、未控制的血压和合并症。结论：降压药物依从率较低。因此，提高高血压患者的服药依从率，以实现有效的血压控制，减轻非传染性疾病的负担，势在必行。

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来源期刊

Hipertension y Riesgo Vascular Medicine-Internal Medicine

CiteScore

1.70

自引率

16.70%

发文量

审稿时长

39 days

期刊介绍： La mejor publicación para mantenerse al día en los avances de la lucha contra esta patología. Incluye artículos de Investigación, Originales, Revisiones, Casos clínicos, Aplicación práctica y Resúmenes comentados a la bibliografía internacional. Además, es la Publicación Oficial de la Sociedad española de Hipertensión-Liga Española para la Lucha contra la Hipertensión Arterial.