Characteristics and outcomes of portal vein thrombosis in patients with inflammatory bowel disease in Korea.

IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Korean Journal of Internal Medicine Pub Date : 2024-12-23 DOI:10.3904/kjim.2024.181
Ki Jin Kim, Su-Bin Song, Jung-Bin Park, June Hwa Bae, Ji Eun Baek, Ga Hee Kim, Min-Jun Kim, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Chang Sik Yu, Yong-Sik Yoon, Jong-Lyul Lee, Min Hyun Kim, Ho-Su Lee, Sang Hyoung Park
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Abstract

Background/aims: Portal vein thrombosis (PVT) frequently occurs in patients with inflammatory bowel disease (IBD), particularly when influenced by factors such as abdominal infections, IBD flare-ups, or surgical procedures. The implications of PVT range from immediate issues such as intestinal ischemia to long-term concerns including portal hypertension and its complications. However, there is a notable gap in comprehensive studies on PVT in IBD, especially with the increasing incidence of IBD in Asia. This research aimed to evaluate the clinical features and outcomes of PVT in patients with IBD at a leading hospital in South Korea.

Methods: This retrospective analysis reviewed adult patients diagnosed with both IBD and PVT from 1989 to 2021 at a renowned South Korean medical center. The study focused on patient characteristics, specifics of PVT, administered treatments, and outcomes, all confirmed through enhanced CT scans.

Results: A total of 78 patients met the study's criteria. Notably, only 20.5% (16/78) were treated with oral anticoagulants; however, a vast majority (96.2%; 75/78) achieved complete radiographic resolution (CRR). When comparing patients receiving anticoagulants to those who did not, a significant preference for anticoagulant use was observed in cases where the main portal vein was affected, as opposed to just the left or right veins (p = 0.006). However, multivariable analysis indicated that neither anticoagulant use nor previous surgeries significantly impacted CRR.

Conclusions: Patients with IBD and PVT generally had favorable outcomes, regardless of anticoagulant use.

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韩国炎症性肠病患者门静脉血栓形成的特点和结局。
背景/目的:门静脉血栓形成(PVT)经常发生在炎症性肠病(IBD)患者中,特别是当受到腹部感染、IBD突发或外科手术等因素的影响时。PVT的影响范围从肠缺血等即时问题到门静脉高压及其并发症等长期问题。然而,对IBD中PVT的综合研究存在明显的空白,特别是随着IBD在亚洲发病率的上升。本研究旨在评估韩国一家领先医院IBD患者PVT的临床特征和结果。方法:回顾性分析1989年至2021年在韩国一家著名医疗中心诊断为IBD和PVT的成年患者。该研究的重点是患者的特征、PVT的具体情况、给予的治疗和结果,所有这些都通过增强CT扫描得到证实。结果:共有78例患者符合研究标准。值得注意的是,只有20.5%(16/78)的患者接受口服抗凝治疗;然而,绝大多数人(96.2%;75/78)达到完全放射成像分辨率(CRR)。当比较接受抗凝药物治疗的患者和未接受抗凝药物治疗的患者时,在门静脉主干受到影响的患者中,抗凝药物的使用明显优于仅左右静脉(p = 0.006)。然而,多变量分析表明抗凝剂使用和既往手术均未显著影响CRR。结论:无论是否使用抗凝剂,IBD和PVT患者通常都有良好的预后。
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来源期刊
Korean Journal of Internal Medicine
Korean Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
5.10
自引率
4.20%
发文量
129
审稿时长
20 weeks
期刊介绍: The Korean Journal of Internal Medicine is an international medical journal published in English by the Korean Association of Internal Medicine. The Journal publishes peer-reviewed original articles, reviews, and editorials on all aspects of medicine, including clinical investigations and basic research. Both human and experimental animal studies are welcome, as are new findings on the epidemiology, pathogenesis, diagnosis, and treatment of diseases. Case reports will be published only in exceptional circumstances, when they illustrate a rare occurrence of clinical importance. Letters to the editor are encouraged for specific comments on published articles and general viewpoints.
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