Research progress on N6-Methyladenosine modification in angiogenesis, vasculogenic mimicry, and therapeutic implications in breast cancer.

Abstract

N⁶-methyladenosine (m⁶A) modification is the most common epitranscriptomic modification in eukaryotic RNA and has garnered extensive attention in the context of breast cancer research. The m⁶A modification significantly impacts tumorigenesis and tumor progression by regulating RNA stability, splicing, translation, and degradation. In this review we summarize recent advances in understanding the roles of m⁶A modification in the mechanisms underlying angiogenesis and vasculogenic mimicry in breast cancer. We review how m⁶A modification and associated transcripts influence relevant factors by affecting key factors and signaling pathways, highlighting the interactions among m⁶A "writers," "erasers," and "readers," and their overall impact on tumor angiogenesis and vasculogenic mimicry, as well as potential new therapeutic targets.