Humoral response 24 months after the first COVID-19 vaccination in people with HIV with and without diabetes.

IF 3.1 2区 医学 Q3 IMMUNOLOGY AIDS Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI:10.1097/QAD.0000000000004026
Louise Bering, Line Dam Heftdal, Safura-Luise Heidari, Sebastian Rask Hamm, Cecillie Bo Hansen, Dina Leth Møller, Mia Pries-Heje, Kamille Fogh, Rasmus Bo Hasselbalch, Laura Pérez-Alós, Jan Gerstoft, Thomas Benfield, Selina Kikkenborg Berg, Anne Vinggaard Christensen, Nina Marie Birk, Linda Maria Hilsted, Sisse Rye Ostrowski, Ruth Frikke-Schmidt, Erik Sørensen, Kirsten Grønbæk, Henning Bundgaard, Kasper Iversen, Peter Garred, Susanne Dam Nielsen
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Abstract

People with HIV (PWH) and people with diabetes mellitus have increased risk of severe COVID-19, but little is known about humoral response to COVID-19 vaccines in PWH with DM. We investigated SARS-CoV-2 antireceptor-binding domain (anti-RBD) immunoglobulin G (IgG) geometrical concentrations and neutralizing antibody capacity (nAB) in PWH with and without diabetes mellitus. Anti-RBD IgG and nAB in COVID-19-vaccinated PWH were not associated with diabetes mellitus-status or HbA1c 24 months after the initial COVID-19 vaccination.

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患有和不患有糖尿病的艾滋病毒感染者首次接种COVID-19疫苗后24个月的体液反应。
HIV感染者(PWH)和糖尿病患者发生严重COVID-19的风险增加,但对DM患者对COVID-19疫苗的体液反应知之甚少。我们研究了合并和不合并糖尿病的PWH患者的SARS-CoV-2抗受体结合域(anti-RBD)免疫球蛋白G (IgG)几何浓度和中和抗体能力(nAB)。在首次接种COVID-19疫苗后24个月,PWH中抗rbd IgG和nAB与糖尿病状态或HbA1c无关。
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来源期刊
AIDS
AIDS 医学-病毒学
CiteScore
5.90
自引率
5.30%
发文量
478
审稿时长
3 months
期刊介绍: ​​​​​​​​​​​​​​​​​Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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