Association between waist-to-hip ratio and risk of myocardial infarction: a systematic evaluation and meta-analysis.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Frontiers in Cardiovascular Medicine Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI:10.3389/fcvm.2024.1438817

Xiaojuan Zhang, Liu Yang, Cong Xiao, Jiacong Li, Tao Hu, Linfeng Li

{"title":"Association between waist-to-hip ratio and risk of myocardial infarction: a systematic evaluation and meta-analysis.","authors":"Xiaojuan Zhang, Liu Yang, Cong Xiao, Jiacong Li, Tao Hu, Linfeng Li","doi":"10.3389/fcvm.2024.1438817","DOIUrl":null,"url":null,"abstract":"Background: Myocardial infarction(MI) is one of the most serious health threats. Despite the increasing number of clinical methods used to predict the onset of MI, the prediction of MI is still unsatisfactory and necessitates new methods.Objective: To systematically review observational studies from the past two decades on the association between waist-to-hip ratio (WHR) and MI risk.Methods: Original literature on the correlation between WHR and MI was searched in PubMed, Embase, Web of Science, Cochrane Library, Science Direct, CNKI, and Wanfang up to January 31, 2024. Two researchers independently screened, extracted data, and assessed quality using the Newcastle-Ottawa Scale (NOS) and Revman5.3. Meta-analysis with Stata 16.0 calculated the combined Odd ratio (OR) for WHR and MI risk. Heterogeneity was assessed with the I 2 statistic to select the appropriate effects model. Subgroup analysis, meta-regression, sensitivity analysis, and funnel plots tested for heterogeneity and publication bias.Results: A total of 22 observational studies were included, involving 709,093 participants. The meta-analysis showed that an elevated WHR was significantly associated with an increased risk of MI, with a pooled odds ratio (OR) of 1.98 [95% Confidence interval (CI): 1.75-2.24] and high heterogeneity (I 2 = 91.5%, P < 0.0001). Subgroup analysis revealed a stronger association between WHR and MI in women (OR: 1.99, 95% CI: 1.43-2.77) compared to men (OR: 1.74, 95% CI: 1.36-2.22). Regional analysis indicated that the association between WHR and MI risk was highest in Asian populations (OR: 2.93 95% CI: 1.61-5.33), followed by American (OR: 1.73, 95% CI: 1.45-2.08) and European populations (OR: 2.19, 95% CI: 1.49-3.22). Sensitivity analysis demonstrated that the results remained stable after excluding one study.Conclusion: In the general adult population, a higher WHR is a potentially significant association for MI and has predictive value for MI.","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1438817"},"PeriodicalIF":2.8000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664439/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cardiovascular Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fcvm.2024.1438817","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Myocardial infarction(MI) is one of the most serious health threats. Despite the increasing number of clinical methods used to predict the onset of MI, the prediction of MI is still unsatisfactory and necessitates new methods.

Objective: To systematically review observational studies from the past two decades on the association between waist-to-hip ratio (WHR) and MI risk.

Methods: Original literature on the correlation between WHR and MI was searched in PubMed, Embase, Web of Science, Cochrane Library, Science Direct, CNKI, and Wanfang up to January 31, 2024. Two researchers independently screened, extracted data, and assessed quality using the Newcastle-Ottawa Scale (NOS) and Revman5.3. Meta-analysis with Stata 16.0 calculated the combined Odd ratio (OR) for WHR and MI risk. Heterogeneity was assessed with the I ² statistic to select the appropriate effects model. Subgroup analysis, meta-regression, sensitivity analysis, and funnel plots tested for heterogeneity and publication bias.

Results: A total of 22 observational studies were included, involving 709,093 participants. The meta-analysis showed that an elevated WHR was significantly associated with an increased risk of MI, with a pooled odds ratio (OR) of 1.98 [95% Confidence interval (CI): 1.75-2.24] and high heterogeneity (I ² = 91.5%, P < 0.0001). Subgroup analysis revealed a stronger association between WHR and MI in women (OR: 1.99, 95% CI: 1.43-2.77) compared to men (OR: 1.74, 95% CI: 1.36-2.22). Regional analysis indicated that the association between WHR and MI risk was highest in Asian populations (OR: 2.93 95% CI: 1.61-5.33), followed by American (OR: 1.73, 95% CI: 1.45-2.08) and European populations (OR: 2.19, 95% CI: 1.49-3.22). Sensitivity analysis demonstrated that the results remained stable after excluding one study.

Conclusion: In the general adult population, a higher WHR is a potentially significant association for MI and has predictive value for MI.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

腰臀比与心肌梗死风险的关系：一项系统评价和荟萃分析。

背景：心肌梗死（MI）是最严重的健康威胁之一。尽管越来越多的临床方法用于预测心肌梗死的发生，但心肌梗死的预测仍然令人不满意，需要新的方法。目的：系统回顾过去二十年来关于腰臀比（WHR）与心肌梗死风险之间关系的观察性研究。方法：检索截至2024年1月31日PubMed、Embase、Web of Science、Cochrane Library、Science Direct、CNKI、万方等网站关于WHR与MI相关性的原始文献。两名研究人员独立筛选、提取数据，并使用纽卡斯尔-渥太华量表（NOS）和Revman5.3评估质量。使用Stata 16.0进行meta分析，计算WHR和MI风险的综合奇数比（OR）。采用i2统计量评估异质性，选择合适的效应模型。亚组分析、meta回归、敏感性分析和漏斗图检验异质性和发表偏倚。结果：共纳入22项观察性研究，涉及709093名受试者。荟萃分析显示，腰腰比升高与心肌梗死风险增加显著相关，合并优势比（OR）为1.98[95%可信区间（CI）： 1.75-2.24]，异质性较高（I 2 = 91.5%， P）。结论：在一般成人人群中，腰腰比升高与心肌梗死有潜在的显著相关性，对心肌梗死具有预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.80

自引率

11.10%

发文量

3529

审稿时长

14 weeks

期刊介绍： Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.