Characteristics of Pediatric Ulcerative Colitis at Diagnosis in Korea: Results From a Multicenter, Registry-Based, Inception Cohort Study.

IF 3 3区医学 Q1 MEDICINE, GENERAL & INTERNAL Journal of Korean Medical Science Pub Date : 2024-12-23 DOI:10.3346/jkms.2024.39.e303

Jin Gyu Lim, Ben Kang, Seak Hee Oh, Eell Ryoo, Yu Bin Kim, Yon Ho Choe, Yeoun Joo Lee, Minsoo Shin, Hye Ran Yang, Soon Chul Kim, Yoo Min Lee, Hong Koh, Ji Sook Park, So Yoon Choi, Su Jin Jeong, Yoon Lee, Ju Young Chang, Tae Hyeong Kim, Jung Ok Shim, Jin Soo Moon

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Abstract

Background: We aimed to investigate the characteristics of pediatric ulcerative colitis (UC) at diagnosis in Korea.

Methods: This was a multicenter, registry-based, inception cohort study conducted in Korea between 2021 and 2023. Children and adolescents newly diagnosed with UC < 18 years were included. Baseline clinicodemographics, results from laboratory, endoscopic exams, and Paris classification factors were collected, and associations between factors at diagnosis were investigated.

Results: A total 205 patients with UC were included. Male-to-female ratio was 1.59:1, and the median age at diagnosis was 14.7 years (interquartile range 11.9-16.2). Disease extent of E1 comprised 12.2% (25/205), E2 24.9% (51/205), E3 11.2% (23/205), and E4 51.7% (106/205) of the patients. S1 comprised 13.7% (28/205) of the patients. The proportion of patients with a disease severity of S1 was significantly higher in patients with E4 compared to the other groups (E1: 0% vs. E2: 2% vs. E3: 0% vs. E4: 24.5%, P < 0.001). Significant differences between disease extent groups were also observed in Pediatric Ulcerative Colitis Activity Index (median 25 vs. 35 vs. 40 vs. 45, respectively, P < 0.001), hemoglobin (median 13.5 vs. 13.2 vs. 11.6 vs. 11.4 g/dL, respectively, P < 0.001), platelet count (median 301 vs. 324 vs. 372 vs. 377 × 10³/μL, respectively, P = 0.001), C-reactive protein (median 0.05 vs. 0.10 vs. 0.17 vs. 0.38 mg/dL, respectively, P < 0.001), and Ulcerative Colitis Endoscopic Index of Severity (median 4 vs. 4 vs. 4 vs. 5, respectively, P = 0.006). No significant differences were observed in factors between groups divided according to sex and diagnosis age.

Conclusion: This study represents the largest multicenter pediatric inflammatory bowel disease cohort in Korea. Disease severity was associated with disease extent in pediatric patients with UC at diagnosis.

Trial registration: Clinical Research Information Service Identifier: KCT0008723.

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韩国儿童溃疡性结肠炎的诊断特点：来自多中心、基于登记的初始队列研究的结果。

背景：我们旨在调查韩国儿童溃疡性结肠炎（UC）的诊断特点。方法：这是一项多中心、基于注册的初始队列研究，于2021年至2023年在韩国进行。包括新诊断为UC < 18岁的儿童和青少年。收集基线临床人口学、实验室结果、内窥镜检查和Paris分类因素，并调查诊断时各因素之间的相关性。结果：共纳入205例UC患者。男女比例为1.59:1，诊断时中位年龄为14.7岁（四分位数间距11.9 ~ 16.2）。E1型占12.2% (25/205)，E2型占24.9% (51/205)，E3型占11.2% (23/205)，E4型占51.7%（106/205）。S1占13.7%（28/205）。E4患者中S1严重程度的患者比例明显高于其他组（E1: 0% vs E2: 2% vs E3: 0% vs E4: 24.5%, P < 0.001）。小儿溃疡性结肠炎活动指数（中位数分别为25、35、40、45，P < 0.001）、血红蛋白（中位数分别为13.5、13.2、11.6、11.4 g/dL, P < 0.001）、血小板计数（中位数分别为301、324、372、377 × 10³/μL， P = 0.001）、c反应蛋白（中位数分别为0.05、0.10、0.17、0.38 mg/dL, P < 0.001）、溃疡性结肠炎内镜下严重程度指数（中位数分别为4比4比4比4比5，P = 0.006）。按性别和诊断年龄分组的各因素无显著差异。结论：本研究是韩国最大的多中心儿童炎症性肠病队列研究。在诊断为UC的儿童患者中，疾病严重程度与疾病程度相关。试验注册：临床研究信息服务标识：KCT0008723。

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来源期刊

Journal of Korean Medical Science 医学-医学：内科

CiteScore

7.80

自引率

8.90%

发文量

320

审稿时长

3-6 weeks

期刊介绍： The Journal of Korean Medical Science (JKMS) is an international, peer-reviewed Open Access journal of medicine published weekly in English. The Journal’s publisher is the Korean Academy of Medical Sciences (KAMS), Korean Medical Association (KMA). JKMS aims to publish evidence-based, scientific research articles from various disciplines of the medical sciences. The Journal welcomes articles of general interest to medical researchers especially when they contain original information. Articles on the clinical evaluation of drugs and other therapies, epidemiologic studies of the general population, studies on pathogenic organisms and toxic materials, and the toxicities and adverse effects of therapeutics are welcome.