Association between muscular atrophy and mortality risk in patients with COPD: a systematic review.

IF 3.3 3区医学 Q2 RESPIRATORY SYSTEM Therapeutic Advances in Respiratory Disease Pub Date : 2024-01-01 DOI:10.1177/17534666241304626

Wenyan Li, Ying Wu, Xun Yang, Jing Zhu, Mei Feng, Rong Deng, Cui Yang, Chengcheng Sun

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Abstract

Background: Muscular atrophy often can be seen at the end of stage in many chronic diseases. It will also negatively influence patients' outcomes. Different studies showed that the association between muscular atrophy and mortality in patients with chronic obstructive pulmonary disease (COPD) was unclear. This study will continue to assess the influence of muscular atrophy on mortality in patients with COPD.

Objectives: To systematically evaluate the association between muscular atrophy and death in patients with COPD.

Design: Systematic review.

Methods and data sources: A systematic review and meta-analysis was conducted. Databases including PubMed, Web of Science, Embase, the Cochrane Library, the China Biomedical Literature Service System, China Biomedical Literature Service System (CINAHL), China National Knowledge Infrastructure, the Wanfang database, and the WeiPu (VIP) were systematically searched for cohort studies on muscular atrophy and COPD from inception to July 1st, 2023. Two reviewers independently review, assess, and extract data from the included studies. Meta-analysis was performed using RevMan 5.4 software.

Results: Thirteen cohort studies were ultimately included, involving 10,528 patients with COPD. There were seven cohort studies included in the meta-analysis, including 3,458 COPD patients. The meta-analysis showed that patients with COPD combined with muscular atrophy had a higher mortality risk (HR = 2.20, 95%CI (1.74, 2.79), p < 0.00001). At the same time, patients with COPD who had muscular atrophy may had longer hospital stays.

Conclusion: Muscular atrophy is associated with the mortality and disease prognosis of patients with COPD. The conclusion needs to be supported and validated by more high-quality studies given the limitation of the number of articles included in this study.

Trial registration: This systematic review protocol was prospectively registered with PROSPERO (No. CRD42024589435).

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慢性阻塞性肺病患者肌肉萎缩与死亡风险之间的关系：一项系统综述。

背景：在许多慢性疾病的终末期经常可以看到肌肉萎缩。它还会对患者的预后产生负面影响。不同的研究表明，慢性阻塞性肺疾病（COPD）患者肌肉萎缩与死亡率之间的关系尚不清楚。本研究将继续评估肌肉萎缩对COPD患者死亡率的影响。目的：系统评价慢性阻塞性肺病患者肌肉萎缩与死亡之间的关系。设计：系统回顾。方法和数据来源：进行系统综述和荟萃分析。系统检索PubMed、Web of Science、Embase、Cochrane Library、中国生物医学文献服务系统、中国生物医学文献服务系统（CINAHL）、中国国家知识基础设施、万方数据库、微普数据库（VIP）等数据库，检索自成立至2023年7月1日肌萎缩症和慢性阻塞性肺病的队列研究。两名审稿人独立地审查、评估并从纳入的研究中提取数据。采用RevMan 5.4软件进行meta分析。结果：最终纳入13项队列研究，涉及10528例COPD患者。meta分析纳入了7项队列研究，包括3458名COPD患者。荟萃分析显示，COPD合并肌肉萎缩患者的死亡风险更高(HR = 2.20, 95%CI (1.74, 2.79)， p结论：肌肉萎缩与COPD患者的死亡率和疾病预后相关。鉴于本研究纳入的文献数量有限，结论需要更多高质量研究的支持和验证。试验注册：该系统评价方案在普洛斯彼罗（PROSPERO）前瞻性注册。CRD42024589435)。

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来源期刊

Therapeutic Advances in Respiratory Disease RESPIRATORY SYSTEM-

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Therapeutic Advances in Respiratory Disease delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of respiratory disease.