Coconut Oil Mitigates the Effects of Aging on the Mongolian Gerbil Prostate.

IF 2.6 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Prostate Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI:10.1002/pros.24842

Luiz Henrique Alves Guerra, Nayara Fernanda da Costa Castro, Fernanda Costa Jubilato, Letícia Aparecida Marques, Ellen Cristina Rivas Leonel, Stanislau Bogusz Junior, Silvana Gisele Pegorin Campos, Paula Rahal, Sebastião Roberto Taboga, Marilia Freitas Calmon, Patrícia Simone Leite Vilamaior

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Abstract

Background: Benign prostatic hyperplasia (BPH) is a disease linked to the hormonal imbalance that occurs during aging and over the last decades, complementary and alternative medicines have come on the scene as a treatment option for BPH, such as herbal medicines. Coconut oil has been shown to be capable of interfering in testosterone-induced BPH. However, until now there is no study of the effect of coconut oil during aging. The present study evaluated the effect of the intake of coconut oil on the prostate of aging gerbils (Meriones unguiculatus).

Methods: Two experimental groups were assigned: Gavage control (GC-animals subjected to gavage with water for 1 year, n = 11) and coconut oil (CO-animals subjected to gavage with coconut oil for 1 year, n = 11). Testosterone, and estradiol serum levels were determined by ELISA assay and histopathological analysis employed Hematoxylin-Eosin. Cell proliferation index was determined by PHH3 immunohistochemistry and TUNEL assay and receptors of androgen (AR) and estrogen (ERα and ERβ) were evaluated on the prostate.

Results: The CO group exhibited a lower prostate weight (↓16.62%), decreased thickness of the prostate muscle stroma (↓18.27%), reduced expression of both AR (↓51.32) and ERα (↓14.26%) and reduced the percentage of BPH (↓1.53%) and intraepithelial neoplasms in the prostate (↓14.24%). Coconut oil intake mitigated age-related changes and increased the rate of apoptosis in prostatic cells (↑54.32).

Conclusions: Coconut oil treatment throughout aging helped counteract the negative effects of aging on prostate health.

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椰子油减轻衰老对蒙古沙鼠前列腺的影响。

背景：良性前列腺增生（BPH）是一种与衰老过程中发生的激素失衡有关的疾病，在过去的几十年里，补充和替代药物已经成为治疗BPH的一种选择，例如草药。椰子油已被证明能够干扰睾丸激素诱导的前列腺增生。然而，到目前为止，还没有研究椰子油对衰老的影响。本研究评价了摄入椰子油对衰老沙鼠前列腺的影响。方法：分为两个实验组：灌胃对照组（gc -动物灌胃1年，n = 11）和椰子油组（co -动物灌胃1年，n = 11）。采用ELISA法测定血清睾酮、雌二醇水平，采用苏木精-伊红进行组织病理学分析。采用PHH3免疫组化和TUNEL法检测细胞增殖指数，检测前列腺雄激素受体（AR）和雌激素受体（ERα和ERβ）水平。结果：CO组前列腺重量降低（↓16.62%），前列腺肌间质厚度降低（↓18.27%），AR表达降低（↓51.32），ERα表达降低（↓14.26%），前列腺增生比例降低（↓1.53%），上皮内肿瘤比例降低（↓14.24%）。摄入椰子油可以减轻年龄相关的变化，并增加前列腺细胞的凋亡率（^ 54.32）。结论：椰子油治疗在整个衰老过程中有助于抵消衰老对前列腺健康的负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostate 医学-泌尿学与肾脏学

CiteScore

5.10

自引率

3.60%

发文量

180

审稿时长

1.5 months

期刊介绍： The Prostate is a peer-reviewed journal dedicated to original studies of this organ and the male accessory glands. It serves as an international medium for these studies, presenting comprehensive coverage of clinical, anatomic, embryologic, physiologic, endocrinologic, and biochemical studies.