The Impact of Deep Local Lung Hyperthermia on COVID-19 Cancer Patients.

Abstract

Background: The goal of this study was to assess the impact of deep local hyperthermia on oxygen (O₂) saturation and infected volumes of lungs on coronavirus disease 2019 (COVID-19) cancer patients.

Materials and methods: Fifty patients who suffered from COVID-19 (according to their computed tomography (CT) images and laboratory findings) were included in this study. The mentioned patients were divided into two groups (I and II) with thirty-five participants. The infected volumes and COVID-19 infectious locations were diagnosed using their CT images, and deep local hyperthermia was performed for group II. After three consequent days, the SPO_2, D-dimer, and infected volumes of lung parenchyma of both groups were compared to each other.

Results: For group II, the mean ± SD (standard deviation) of O₂ pressure saturation (SPO₂) before/after hyperthermia was 85 ± 0.0/91.3 ± 0.5, respectively, while for group I, the mean ± SD of SPO₂ before/after 3 days was 85 ± 0.0/88 ± 0.2, respectively. For infected volumes of lungs before/after hyperthermia in group II, the mean ± SD was 31.36 ± 3.13/4 ± 1.53, respectively. Nonetheless, the infected volumes of lungs for group I were 34.21 ± 3.41/10 ± 2.12 before/after three days. For group II, the amount of D-dimer before/after hyperthermia was 3200 ± 106/510 ± 121, respectively. However, for group I, it was 3100/740 before/after the consequent three days, respectively.

Conclusion: Deep local lung hyperthermia for COVID-19 cancer patients is suggested, as a result of its positive impacts on SPO₂ improvement and also D-dimer serum level, C-reactive protein, and Lactate dehydrogenaze reduction for the mentioned patients.