Amine-Promoted Three-Component Radical Selenofunctionalization for the Construction of β-Hydroxy Selenide Derivatives

IF 3.6 2区 化学 Q1 CHEMISTRY, ORGANIC Journal of Organic Chemistry Pub Date : 2024-12-28 DOI:10.1021/acs.joc.4c02149
Jiantao Zhang, Renhua Su, Peng Zhou, Cui Chen, Weibing Liu
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Abstract

An amine-promoted three-component radical selenofunctionalization reaction of alkenes with TBHP and diselenide is disclosed. The reaction conditions are mild and suitable for a wide range of substrates (29 examples), and all give the corresponding hydroxyselenenylation products in moderate to excellent yields. In addition, preliminary studies on the mechanism reveal that the current method might proceed via a radical pathway. TBHP serves as both radical initiator and the source of hydroxyl group.

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胺促进三组分自由基硒功能化构建β-羟基硒化物衍生物
公开了一种胺促进的烯烃与三必和二硒化物的三组分自由基硒化反应。反应条件温和,适用于广泛的底物(29个例子),并且都能以中等到优异的产率产生相应的羟硒化产物。此外,对机理的初步研究表明,目前的方法可能是通过自由基途径进行的。三必拓既是自由基引发剂,又是羟基的来源。
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来源期刊
Journal of Organic Chemistry
Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍: Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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