{"title":"Anti-Markovnikov Hydroacylation of Aryl Alkenes with Aldehydes Enabled by Photo/Cobalt Dual Catalysis","authors":"Guanghao Ji, Xuan Li, Jing Zhang","doi":"10.1021/acs.orglett.4c04373","DOIUrl":null,"url":null,"abstract":"Herein we describe a dual photo/cobalt-catalyzed anti-Markovnikov hydroacylation of aryl alkenes using aldehyde as acyl source. The key to success is the cobalt catalyzed hydrogen atom transfer, which enables effective formation of the desired products and efficient regeneration of the photocatalyst under mild conditions. This protocol features broad substrate scopes, good functional group tolerance, high efficiency and regioselectivity.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"51 1","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Letters","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.orglett.4c04373","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Herein we describe a dual photo/cobalt-catalyzed anti-Markovnikov hydroacylation of aryl alkenes using aldehyde as acyl source. The key to success is the cobalt catalyzed hydrogen atom transfer, which enables effective formation of the desired products and efficient regeneration of the photocatalyst under mild conditions. This protocol features broad substrate scopes, good functional group tolerance, high efficiency and regioselectivity.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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