Nickel(II) Complexes Based on Pyridyl- and Quinolyl-Containing Dialkylphosphine Oxides

IF 1.2 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR Journal of Structural Chemistry Pub Date : 2024-12-27 DOI:10.1134/S0022476624120138

K. R. Enikeeva, I. A. Litvinov, A. P. Lyubina, A. D. Voloshina, E. I. Musina, A. A. Karasik

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Abstract

The [Ni(L1)₂(H₂O)₂](BF₄)₂(1-H₂O) and [Ni(L2)₂](BF₄)₂ (2) bis-chelate nickel(II) complexes based on 1,5-N,O-ligands, namely, (diisopropyl(pyridin-2-ylmethyl)phosphine oxide L1 and diisopropyl(quinolin-2-ylmethyl)phosphine oxide L2) are prepared. The structure and composition of 1-H₂O and 2 are confirmed by mass spectroscopy, IR spectroscopy, thermogravimetric analysis, and elemental analysis. The compounds dissociate in solutions so that aqualigands in 1-H₂O are replaced by acetonitrile to form the [Ni(L1)₂(CH₃CN)₂](BF₄)₂(1-CH₃CN) complex and phosphine oxide ligands in 2 are replaced by six water molecules to form the [Ni₂(L2)₄(H₂O)₁₂](BF₄)₂ hydrogen-bonded hexaaquanickel(II) agglomerate (3). The structure of 1-H₂O, 1-CH₃CN, and 3 in crystals are determined by XRD. Cytotoxic properties of the synthesized nickel(II) complexes against M-HeLa and HuTu80 cancer cells and normal Chang Liver cell lines are studied.

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含吡啶基和喹啉基二烷基膦氧化物的镍（II）配合物

制备了基于1,5- n- o配体的[Ni(L1)2(H2O)2](BF4)2（1-H2O）和[Ni(L2)2](BF4)2(2)双螯合镍（II）配合物，即（二异丙基（吡啶-2-基甲基）氧化膦L1和二异丙基（喹啉-2-基甲基）氧化膦L2）。通过质谱、红外光谱、热重分析和元素分析证实了1-H2O和2的结构和组成。化合物在溶液中解离，1-H2O中的水合体被乙腈取代形成[Ni(L1)2(CH3CN)2](BF4)2（1-CH3CN）配合物，2中的氧化膦配体被6个水分子取代形成[Ni2(L2)4(H2O)12](BF4)2氢键六水镍（II）团块(3)。用XRD测定了1-H2O、1-CH3CN和3 in晶体的结构。研究了合成的镍（II）配合物对M-HeLa、HuTu80癌细胞和正常常肝细胞株的细胞毒性。

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来源期刊

Journal of Structural Chemistry 化学-无机化学与核化学

CiteScore

1.60

自引率

12.50%

发文量

142

审稿时长

8.3 months

期刊介绍： Journal is an interdisciplinary publication covering all aspects of structural chemistry, including the theory of molecular structure and chemical bond; the use of physical methods to study the electronic and spatial structure of chemical species; structural features of liquids, solutions, surfaces, supramolecular systems, nano- and solid materials; and the crystal structure of solids.