Bioinspired Design of an Underwater Adhesive Based on Tea Polyphenol-Modified Silk Fibroin.

IF 5.4 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2025-01-13 Epub Date: 2024-12-27 DOI:10.1021/acsbiomaterials.4c01659
Jialuo Chen, Zhipeng Li, Xinpeng Chen, Yurong Sun, Jin Cheng, Aijing Li, Shenzhou Lu, Tieling Xing
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Abstract

Adhesives have garnered significant interest recently due to their application in the field of biomedical applications. Nonetheless, developing adhesives that exhibit robust underwater adhesion and possess antimicrobial properties continues to pose a significant challenge. In this study, motivated by the adhesive mechanism observed in mussels in aquatic environments, dopamine (DA) was added to modify the silk fibroin (SF) solution. Subsequently, tea polyphenol (TP) was incorporated to form a sticky mixture, resulting in a biomimetic adhesive (TP-DA/SF). TP-DA/SF demonstrated rapid, robust, and indiscriminate adhesion to a wide array of substrates and even biological tissues (39 kPa). TP-DA/SF exhibits the ability to replicate the mussel adhesion mechanism of mussels underwater thanks to its biomimetic design. This characteristic provides the material with robust adhesion (40 kPa), notable reusability (at least 10 times), and long-lasting stability, especially in aquatic settings. It is worth noting that TP-DA/SF also demonstrated high adhesion in various water environments, even in solutions with a pH of 7.4 and buffered saline (PBS), which is one of the most widely used buffers in biochemistry research, offering salt-balancing and adjustable pH buffering capabilities. Meanwhile, TP-DA/SF exhibits excellent antibacterial and antioxidant properties due to its tea polyphenol content. After 15 days of wound closure in SD rats, the healing rate in the experimental group reached 93.4%, compared to 83.9% in the control group. Thus, the TP-DA/SF adhesive holds promising potential for biomedical applications, including sutureless wound closure and tissue adhesion.

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基于茶多酚改性丝素蛋白的水下粘合剂的仿生设计。
胶粘剂由于其在生物医学领域的应用而引起了人们的极大兴趣。尽管如此,开发具有强大水下附着力和抗菌性能的粘合剂仍然是一个重大挑战。本研究基于在水生环境中观察到的贻贝黏附机制,将多巴胺(DA)加入到丝素(SF)溶液中进行修饰。随后,加入茶多酚(TP)形成粘性混合物,得到仿生粘合剂(TP- da /SF)。TP-DA/SF表现出对多种底物甚至生物组织的快速、稳健和不加区分的粘附能力(39 kPa)。TP-DA/SF具有仿生学设计,能够复制贻贝在水下的粘附机制。这种特性使材料具有强大的附着力(40千帕),显著的可重复使用性(至少10次)和持久的稳定性,特别是在水生环境中。值得注意的是,TP-DA/SF在各种水环境中也表现出高粘附性,即使在pH为7.4的溶液和缓冲盐水(PBS)中也是如此,缓冲盐水是生物化学研究中最广泛使用的缓冲液之一,具有盐平衡和可调节pH缓冲能力。同时,TP-DA/SF因其茶多酚含量而表现出优异的抗菌和抗氧化性能。SD大鼠伤口闭合15天后,实验组愈合率达93.4%,对照组为83.9%。因此,TP-DA/SF胶粘剂在生物医学应用方面具有很大的潜力,包括无缝线伤口闭合和组织粘附。
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阿拉丁
LiBr
阿拉丁
Na2CO3
阿拉丁
NaHCO3
阿拉丁
Urea
阿拉丁
Tea polyphenols
阿拉丁
Dopamine hydrochloride
阿拉丁
LiBr
阿拉丁
Na2CO3
阿拉丁
NaHCO3
阿拉丁
Urea
阿拉丁
Tea polyphenols (TP)
阿拉丁
Dopamine hydrochloride (DA-HCl)
阿拉丁
LiBr
阿拉丁
Na<sub>2</sub>CO<sub>3</sub>
阿拉丁
NaHCO<sub>3</sub>
阿拉丁
Urea
阿拉丁
Tea polyphenols (TP)
阿拉丁
Dopamine hydrochloride (DA-HCl)
来源期刊
ACS Biomaterials Science & Engineering
ACS Biomaterials Science & Engineering Materials Science-Biomaterials
CiteScore
10.30
自引率
3.40%
发文量
413
期刊介绍: ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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