Beyond protein folding: The pleiotropic functions of PPIases in cellular processes and microbial virulence

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. General subjects Pub Date : 2025-02-01 DOI:10.1016/j.bbagen.2024.130754

Roopshali Rakshit , Aayush Bahl , Arunima Arunima , Saurabh Pandey , Deeksha Tripathi

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Abstract

Peptidyl prolyl cis/trans isomerases (PPIases), a ubiquitously distributed superfamily of enzymes, associated with signal transduction, trafficking, assembly, biofilm formation, stress tolerance, cell cycle regulation, gene expression and tissue regeneration, is a key regulator of metabolic disorders and microbial virulence. This review assumes an integrative approach, to provide a holistic overview of the structural and functional diversity of PPIases, examining their conformational dynamics, cellular distribution, and physiological significance. We explore their intricate involvement in cellular processes and virulence modulation in both eukaryotic and prokaryotic systems. Additionally, we evaluate the potential of these molecular chaperones as drug targets and vaccine candidates, emphasizing their relevance in therapeutic development. By synthesizing recent findings and providing a broader perspective on these proteins, this review aims to enhance our understanding of their multifaceted roles in biology and their potential applications in medicine.

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超越蛋白质折叠：PPIases在细胞过程和微生物毒力中的多效性功能。

肽基脯氨酸顺/反式异构酶（PPIases）是一个普遍存在的酶超家族，与信号转导、运输、组装、生物膜形成、胁迫耐受性、细胞周期调节、基因表达和组织再生有关，是代谢紊乱和微生物毒力的关键调节因子。本文采用综合的方法，对PPIases的结构和功能多样性进行了全面的概述，研究了它们的构象动力学、细胞分布和生理意义。我们探讨了它们在真核和原核系统中细胞过程和毒力调节的复杂参与。此外，我们评估了这些分子伴侣作为药物靶点和候选疫苗的潜力，强调了它们在治疗发展中的相关性。本文通过对这些蛋白质的最新研究结果进行综合，并从更广阔的角度对其进行综述，旨在提高我们对其在生物学中的多方面作用及其在医学上的潜在应用的理解。

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来源期刊

Biochimica et biophysica acta. General subjects 生物-生化与分子生物学

CiteScore

6.40

自引率

0.00%

发文量

139

审稿时长

30 days

期刊介绍： BBA General Subjects accepts for submission either original, hypothesis-driven studies or reviews covering subjects in biochemistry and biophysics that are considered to have general interest for a wide audience. Manuscripts with interdisciplinary approaches are especially encouraged.