Erratum for the research article “The suppressive efficacy of THZ1 depends on KRAS mutation subtype and is associated with super-enhancer activity and the PI3K/AKT/mTOR signalling in pancreatic ductal adenocarcinoma: A hypothesis-generating study” by Huang et al

IF 6.8 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Translational Medicine Pub Date : 2024-12-27 DOI:10.1002/ctm2.70158
Lei Huang, Hui Yang, Kaidi Chen, Jing Yuan, Jie Li, Guanghai Dai, Mancang Gu, Yan Shi
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Abstract

Some inadvertent mistake in our paper entitled “The suppressive efficacy of THZ1 depends on KRAS mutation subtype and is associated with super-enhancer activity and the PI3K/AKT/mTOR signalling in pancreatic ductal adenocarcinoma: A hypothesis-generating study” [1] and published in Clinical and translational medicine came to our attention recently:

(1) There was an unintentional mistake in the placement and assembly of representative individual bioluminescence images in the original Figure 2A, which does not impact the statistical analysis, the described findings, or the conclusions. We would like to correct the representative individual bioluminescence image in the red block of the original Figure 2A as (Figure 1):

(2) There was an unintentional mistake in loading control band placement in Western blot, which does not influence the described findings or the conclusions. We would like to correct the loading control GAPDH in the red block of the original Figure 1I as (Figure 2).

And correct the loading control GAPDH in the red block of the original Figure 5C and E as (Figure 3):

The corrections do not have any impact on the described findings, the conclusions, or any other part of the manuscript. We sincerely apologize for any inconvenience caused.

Abstract Image

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Huang等人的研究文章《THZ1的抑制作用取决于KRAS突变亚型,并与胰腺导管腺癌中的超增强子活性和PI3K/AKT/mTOR信号传导相关:一项假设生成研究》的更正。
在我们题为“THZ1的抑制作用取决于KRAS突变亚型,并与胰腺导管腺癌中的超增强子活性和PI3K/AKT/mTOR信号传导有关”的论文中出现了一些无意的错误:最近,发表在《临床与转化医学》杂志上的一项假设生成研究[1]引起了我们的注意:(1)原始图2A中代表性个体生物发光图像的放置和组装存在无意的错误,这不会影响统计分析、所描述的发现或结论。我们想将原始图2A中红色块中具有代表性的个体生物发光图像纠正为(图1):(2)在Western blot中加载控制带放置时出现了无意的错误,这并不影响描述的结果或结论。我们希望将原图1I中红色区域的加载控制GAPDH更正为(图2),并将原图5C和E中红色区域的加载控制GAPDH更正为(图3):这些更正不会对所描述的发现、结论或手稿的任何其他部分产生任何影响。对于由此造成的不便,我们深表歉意。
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来源期刊
CiteScore
15.90
自引率
1.90%
发文量
450
审稿时长
4 weeks
期刊介绍: Clinical and Translational Medicine (CTM) is an international, peer-reviewed, open-access journal dedicated to accelerating the translation of preclinical research into clinical applications and fostering communication between basic and clinical scientists. It highlights the clinical potential and application of various fields including biotechnologies, biomaterials, bioengineering, biomarkers, molecular medicine, omics science, bioinformatics, immunology, molecular imaging, drug discovery, regulation, and health policy. With a focus on the bench-to-bedside approach, CTM prioritizes studies and clinical observations that generate hypotheses relevant to patients and diseases, guiding investigations in cellular and molecular medicine. The journal encourages submissions from clinicians, researchers, policymakers, and industry professionals.
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