Approved natural products-derived nanomedicines for disease treatment

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Chinese Journal of Natural Medicines Pub Date : 2024-12-01 DOI:10.1016/S1875-5364(24)60726-0

Xiaotong LI , Yaoyao LAI , Guanghan WAN , Jiahui ZOU , Wei HE , Pei YANG

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Abstract

In recent years, there has been an increasing emphasis on exploring innovative drug delivery approaches due to the limitations of conventional therapeutic strategies, such as inadequate drug targeting, insufficient therapeutic efficacy, and significant adverse effects. Nanomedicines have emerged as a promising solution with notable advantages, including extended drug circulation, targeted delivery, and improved bioavailability, potentially enhancing the clinical treatment of various diseases. Natural products/materials-derived nanomedicines, characterized by their natural therapeutic efficacy, superior biocompatibility, and safety profile, play a crucial role in nanomedicine-based treatments. This review provides a comprehensive overview of currently approved natural products-derived nanomedicines, emphasizing the essential properties of natural products-derived drug carriers, their applications in clinical diagnosis and treatment, and the current therapeutic potential and challenges. The aim is to offer guidance for the application and further development of these innovative therapeutic approaches.

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经批准用于疾病治疗的天然产品衍生纳米药物。

近年来，由于传统治疗策略的局限性，如药物靶向性不足、治疗效果不足、不良反应明显等，人们越来越重视探索创新的给药途径。纳米药物已成为一种有前景的解决方案，具有显著的优势，包括延长药物循环，靶向递送和提高生物利用度，可能增强各种疾病的临床治疗。天然产物/材料衍生的纳米药物以其天然的治疗效果、优越的生物相容性和安全性等特点，在纳米医学治疗中发挥着至关重要的作用。本文综述了目前批准的天然产物衍生纳米药物，重点介绍了天然产物衍生药物载体的基本特性、在临床诊断和治疗中的应用以及目前的治疗潜力和挑战。目的是为这些创新治疗方法的应用和进一步发展提供指导。

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.