Analysis of clinical characteristics and mortality risk factors in patients with community-acquired pneumonia caused by Klebsiella pneumoniae

Abstract

Community-acquired pneumonia (CAP) caused by Klebsiella pneumoniae (KP) results in high mortality. 121 cases were included in this study to explore the characteristics and risk factors of CAP patients caused by hypervirulent or resistant KP strains, which were limited reported in previous studies. We found that neither hypervirulent KP nor ESBL-producing KP infections affect mortality (P > 0.05), while increased qSOFA score (odds ratio [OR] 4.50, 95% confidence interval [CI] 1.55–12.76, P = 0.005) and APACHE-II score (OR 1.30, 95% CI 1.13–1.48, P < 0.001) were independent risk factors for mortality. In addition, the areas under the curve (AUCs) of qSOFA in predicting the mortality rate of all patients, ICU patients, and non-ICU patients were 0.82, 0.74, and 0.81, respectively. Elevated qSOFA or APACHE-II scores were considered independent risk factors for 28-day mortality. The qSOFA score was a good predictor of mortality among KP CAP patients.