Relation of serum irisin levels with adiposity, components of metabolic syndrome and carotid intima media thickness in prepubertal children with obesity: a cross-sectional study.

IF 3.7 3区医学 Q2 Medicine Endocrine Pub Date : 2024-12-26 DOI:10.1007/s12020-024-04139-x

D Herouvi, E A Vlachopapadopoulou, M Vakaki, D Gouriotis, A Marmarinos, C Kalpia, L Kossiva, M Tsolia, K Karavanaki

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Abstract

Aim: Irisin, a newly discovered adipomyokine, has pleiotropic effects in metabolic and energy homeostasis, insulin resistance (IR), and browning of white adipose tissue. The aim of this study was to evaluate irisin levels in children with obesity and also to elucidate possible relationships between irisin with anthropometric obesity indices, parameters of metabolic syndrome (MetS), and intima media thickness (IMT).

Methods: A total of 77 prepubertal children, 4-12 years old, were enrolled in this study, including 44 children with obesity (BMI ≥ 95th percentile) and 33 normal weight controls of matched age and gender. Detailed clinical examination, anthropometric parameters, laboratory data, including serum irisin levels, using ELISA technique and cIMT measurement were carried out in all subjects.

Results: Children with obesity had significantly higher values of irisin compared to controls (p = 0.003) independently of age, gender, or IR status. Irisin levels were positively correlated with weight z-score, Body Mass Index (BMI), BMI z-score, % Body Fat, waist circumference (WC), triglycerides (TG), and HOMA-IR (p = 0.016, p = 0.025, p = 0.028, p = 0.035, p = 0.019, p = 0.049, p = 0.007 respectively) and inversely correlated with HDL (p = 0.037). In multiple regression analysis irisin levels were strongly associated with excess adiposity (p < 0.001) and uric acid (p = 0.054).

Conclusion: Children with obesity showed an unfavorable cardiometabolic profile and higher levels of IMT and irisin. Moreover, irisin was correlated with metabolic parameters, suggesting that irisin can serve as a prognostic index for future development of MetS in children with obesity.

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青春期前肥胖儿童血清鸢尾素水平与肥胖、代谢综合征成分和颈动脉内膜中膜厚度的关系：一项横断面研究。

目的：鸢尾素是一种新发现的脂肪代谢因子，在代谢和能量平衡、胰岛素抵抗（IR）和白色脂肪组织褐变中具有多效作用。本研究的目的是评估肥胖儿童中的鸢尾素水平，并阐明鸢尾素与人体测量肥胖指数、代谢综合征（MetS）参数和内膜中膜厚度（IMT）之间的可能关系。方法：选取年龄在4 ~ 12岁的青春期前儿童77例，其中肥胖（BMI≥95百分位）儿童44例，年龄、性别匹配的体重正常对照33例。对所有受试者进行详细的临床检查、人体测量参数、实验室数据（包括血清鸢尾素水平）、ELISA技术和cIMT测量。结果：与年龄、性别或IR状态无关，肥胖儿童的鸢尾素水平明显高于对照组（p = 0.003）。鸢尾素水平与体重z-score、身体质量指数（BMI）、BMI z-score、体脂%、腰围（WC）、甘油三酯（TG）、HOMA-IR分别呈正相关（p = 0.016、p = 0.025、p = 0.028、p = 0.035、p = 0.019、p = 0.049、p = 0.007），与HDL呈负相关（p = 0.037）。在多元回归分析中，鸢尾素水平与过度肥胖密切相关(p结论：肥胖儿童表现出不利的心脏代谢特征，IMT和鸢尾素水平较高。此外，鸢尾素与代谢参数相关，表明鸢尾素可以作为肥胖儿童未来MetS发展的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.