Three new compounds of Umbelopsis dimorpha VDG10, a dominant endophytic fungus from Vaccinium dunalianum Wight

IF 2.5 3区 医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-12-24 DOI:10.1016/j.fitote.2024.106358
Zhi-Yu Zhang , Xiao-Man Fu , Yuan-Cao Shu , Xu-Jie Qin , Ying-Jun Zhang , Ping Zhao , Xiao-Qin Yang , Li-Hua Zou , Wei-Hua Wang , Guo-Lei Zhu
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Abstract

Three novel compounds, including an aromatic amino acid, dimorine A (1), a suncheonoside derivative, dimoroside A (2), and a phenylpropanoid glycoside, dimoroside B (3), together with four known compounds (47) were separated from Umbelopsis dimorpha VDG10, the predominant endophytic fungus found in the roots of Vaccinium dunalianum Wight (Ericaceae). Their structures were elucidated by spectroscopic methods, and the ECD spectrum confirmed the absolute configuration of 3. In addition, the antifungal activities of novel compounds against five phytopathogenic fungi were evaluated. The results indicated that compound 3 has a better inhibitory effect on Alternaria brassicicola than the broad-spectrum antifungal agent thiabendazole, and its MICs of 15.63–7.82 μg/mL.

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dunalianum Wight的优势内生真菌Umbelopsis dimorpha VDG10的三个新化合物。
从杜鹃根内生真菌Umbelopsis dimoroa VDG10中分离出芳香氨基酸二moroine A(1)、二moroside衍生物二moroside A(2)和苯丙苷二moroside B(3) 3个新化合物和4个已知化合物(4-7)。用光谱学方法鉴定了它们的结构,ECD谱图证实了3的绝对构型。此外,还对新化合物对5种植物病原真菌的抑菌活性进行了评价。结果表明,化合物3对十字花科真菌的抑制效果优于广谱抗真菌剂噻苯达唑,其mic值为15.63 ~ 7.82 μg/mL。
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来源期刊
Fitoterapia
Fitoterapia 医学-药学
CiteScore
5.80
自引率
2.90%
发文量
198
审稿时长
1.5 months
期刊介绍: Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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