Behind the scenes with genomics researchers.

IF 2.8 3区 生物学 Q2 GENETICS & HEREDITY Frontiers in Genetics Pub Date : 2024-12-12 eCollection Date: 2024-01-01 DOI:10.3389/fgene.2024.1467404
Renata Mont'Alverne Bretz Giovanini, Lori Bradford, Cheryl Buckmaster, Graham Strickert, Jason MacLean, Diane Dupont
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Abstract

Although lab-coat genomics scientists are highly skilled and involved in pioneering work, few studies have examined their perceptions on what they do, and how they relate with others in interdisciplinary work. Recognizing that gap, we were curious to talk with scientists about their current work and positionalities related to the use of genomics for bioremediation. Using unstructured open-ended interviews and thematic analysis, we interviewed researchers with diverse genomics-related expertise. Emerging topics were grouped into two broad categories akin to Bronfenbrenner's nested developmental model: microsystem matters, comprising technical advances, barriers, and localized concerns; and macrosystem matters, exploring wider reflections and the philosophies of genomics and society. At the microsystem level, findings revealed differences of opinion about methodological steps, but there was agreement about the incompleteness of databases and the absence of established reference values. These two problems may not only impact a project's progress but also the ability to gauge success, affecting budgeting, human resource needs, and overall stress. At the macrosystem level, scientists voiced concerns about how different social groups perceive and accept genomics applications, as those tend to be viewed by lay persons as genetic interventions. Another focus was on how academic publication slows progress because it is orientated toward positive results while gaps in knowledge could be filled by publishing negative results or methodological barriers. This study underscores scientists' self-awareness within the genomics discipline, acknowledging how their beliefs and biases shape research outcomes. It illuminates critical reflections essential for navigating societal and scientific landscapes in genomics research.

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在幕后与基因组学研究人员。
虽然实验室里的基因组学科学家技能高超,参与了开创性的工作,但很少有研究调查他们对自己所做的事情的看法,以及他们在跨学科工作中如何与他人联系。认识到这一差距后,我们很好奇地与科学家们讨论他们目前在利用基因组学进行生物修复方面的工作和立场。使用非结构化开放式访谈和专题分析,我们采访了具有不同基因组学相关专业知识的研究人员。新兴主题被分为两大类,类似于Bronfenbrenner的嵌套发展模型:微系统问题,包括技术进步、障碍和局部关注;宏观系统很重要,探索更广泛的思考和基因组学和社会的哲学。在微系统一级,调查结果显示了对方法步骤的不同意见,但对数据库不完整和缺乏既定参考值的看法是一致的。这两个问题不仅会影响项目的进度,还会影响评估成功的能力,影响预算、人力资源需求和整体压力。在宏观系统层面上,科学家们对不同的社会群体如何看待和接受基因组学应用表达了担忧,因为这些应用往往被外行人视为基因干预。另一个重点是学术出版如何减缓进展,因为它以积极结果为导向,而知识差距可以通过发表消极结果或方法障碍来填补。这项研究强调了科学家在基因组学领域的自我意识,承认他们的信念和偏见如何影响研究成果。它阐明了在基因组学研究中导航社会和科学景观所必需的批判性反思。
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来源期刊
Frontiers in Genetics
Frontiers in Genetics Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
5.50
自引率
8.10%
发文量
3491
审稿时长
14 weeks
期刊介绍: Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public. The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.
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