Synthetic MRI derived relaxometry parameters: a new insight into characterization of ring enhancing lesions of brain.

IF 2.4 3区医学 Q2 CLINICAL NEUROLOGY Neuroradiology Pub Date : 2024-12-27 DOI:10.1007/s00234-024-03533-6

Sanket Dash, Sameer Vyas, Nidhi Bhardwaj, Chirag Kamal Ahuja, Manish Modi, Rajesh Chhabra, Jitendra Kumar Sahu, Naveen Sankhyan, Paramjeet Singh

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Abstract

Background and purpose: Synthetic MRI utilizes the quantitative relaxometry parameters to generate multiple contrast images through a single acquisition. We tried to explore the utility of synthetic MRI derived relaxometry parameters in evaluation of ring enhancing lesions of brain.

Materials and methods: This was a prospective study. 40 subjects with ring enhancing lesions in brain underwent pre and post contrast synthetic MRI using MDME sequence. Pre and post contrast R1, R2 and PD values were recorded from the core, wall and perilesional edema of lesions and sub group analysis was done among infective, primary neoplastic and secondary neoplastic (metastatic) lesion groups.

Results: Pre and post contrast R1, R2 values from core were higher in the infective group compared to the others. Pre and post contrast R1, R2 values were lower in the wall where as it was significantly higher in the perilesional edema of primary neoplastic group. Post-pre the values increased significantly in the perilesional edema of primary neoplasms. R1 value of ≥ 0.689 and R2 value of ≥ 7.481 in the perilesional edema predicts a primary neoplasm over infection with 70.6% sensitivity and 85.7% specificity and over secondary neoplasm with 64.7% sensitivity and 100% specificity.

Conclusion: Synthetic MRI derived relaxometry parameters in ring enhancing lesions were found to be significantly different across sub groups and can be used to differentiate between primary neoplastic, secondary neoplastic and infective group with parameters from perilesional edema being the most useful.

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来源期刊

Neuroradiology 医学-核医学

CiteScore

5.30

自引率

3.60%

发文量

214

审稿时长

4-8 weeks

期刊介绍： Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.