Acanthamoeba Infection in a Hematopoietic Cell Transplant Recipient: Challenges in Diagnosis, Management, and Source Identification.

IF 2.6 4区医学 Q3 IMMUNOLOGY Transplant Infectious Disease Pub Date : 2024-12-28 DOI:10.1111/tid.14425

Camellia T Banerjee, Sean Conlan, Anahita Mostaghim, Angela Michelin, Matthew Arduino, Mia Mattioli, Julia C Haston, Sanchita Das, Amir Seyedmousavi, Bickey H Chang, Elise M O'Connell, Christopher G Kanakry, Akbulut Dilara, Martha Quezado, Juan Gea-Banacloche, Clay Deming, Julia A Segre, Alison Han, Jennifer Cuellar-Rodriguez

引用次数: 0

Abstract

We report a case of Acanthamoeba infection in an HCT recipient with steroid-refractory GVHD. We highlight the multiple challenges that free-living ameba infections present to the clinician, the clinical laboratory, transplant infectious disease for review, hospital epidemiology if nosocomial transmission is considered, and public health officials, as exposure source identification can be a significant challenge. Transplant physicians should include Acanthamoeba infections in their differential diagnosis of a patient with skin, sinus, lung, and/or brain involvement.

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我们报告了一例类固醇难治性血管内皮细胞增多症（GVHD）造血干细胞移植受者的阿卡阿米巴感染病例。我们强调了游离阿米巴感染给临床医生、临床实验室、移植传染病审查、医院流行病学（如果考虑到院内传播）和公共卫生官员带来的多重挑战，因为暴露源的识别可能是一项重大挑战。移植医生在对皮肤、鼻窦、肺部和/或脑部受累的患者进行鉴别诊断时，应将棘阿米巴感染包括在内。

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来源期刊

Transplant Infectious Disease 医学-传染病学

CiteScore

5.30

自引率

7.70%

发文量

210

审稿时长

4-8 weeks

期刊介绍： Transplant Infectious Disease has been established as a forum for presenting the most current information on the prevention and treatment of infection complicating organ and bone marrow transplantation. The point of view of the journal is that infection and allograft rejection (or graft-versus-host disease) are closely intertwined, and that advances in one area will have immediate consequences on the other. The interaction of the transplant recipient with potential microbial invaders, the impact of immunosuppressive strategies on this interaction, and the effects of cytokines, growth factors, and chemokines liberated during the course of infections, rejection, or graft-versus-host disease are central to the interests and mission of this journal. Transplant Infectious Disease is aimed at disseminating the latest information relevant to the infectious disease complications of transplantation to clinicians and scientists involved in bone marrow, kidney, liver, heart, lung, intestinal, and pancreatic transplantation. The infectious disease consequences and concerns regarding innovative transplant strategies, from novel immunosuppressive agents to xenotransplantation, are very much a concern of this journal. In addition, this journal feels a particular responsibility to inform primary care practitioners in the community, who increasingly are sharing the responsibility for the care of these patients, of the special considerations regarding the prevention and treatment of infection in transplant recipients. As exemplified by the international editorial board, articles are sought throughout the world that address both general issues and those of a more restricted geographic import.