Vessel invasion is a risk factor for gastric cancer: a retrospective analysis study.

IF 2.5 3区医学 Q3 ONCOLOGY World Journal of Surgical Oncology Pub Date : 2024-12-27 DOI:10.1186/s12957-024-03604-1

Qiannan Wang, Zhaorui Liu, Jiangbo Han, Yuan Gao, Yun Shao, Hui Cai, Kai Yin

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Abstract

Objective: To explore the relationship between vessel invasion (VI) and clinicopathological features and prognosis in patients with gastric cancer (GC).

Methods: A total of 3600 cases of patients with GC who underwent radical gastrectomy in gastrointestinal surgery department of the First Affiliated Hospital of Naval Medical University from June 2014 to June 2019 were retrospectively analyzed, and filtering them based on specific inclusion and exclusion criteria. To reduce the possibility of selection bias about the impact of VI, patients were divided into two groups according to the presence or absence of it, and performed a one-to-one propensity score matching (PSM), resulting in 724 patients in each group. In the analysis of data from 3,205 GC patients was employed to examine inter-group variations in VI positivity across diverse clinicopathological factors. Both univariate and multivariate Cox regression models were applied to investigate the correlation between clinicopathological factors and prognosis. The findings were further illustrated through the plotting of Kaplan-Meier survival curves.

Results: 3205 patients were included in this study, of which 989 (30.9%) were VI-positive and 2216 (69.1%) were VI-negative. VI-positive group was found to be significantly associated with age, body mass index (BMI), pTNM stage, tumor location, perineural invasion (PI), Lauren classfication and tumor deposit (TD) (P < .05), but not with gender or basic disease. VI-positive patients had a worse survival than VI-negative patients before (P < .001) and after (P = .007) PSM matching. The Kaplan-Meier survival curve after PSM illustrated that patients with VI had a 5-year survival rate of 58.03%, whereas patients without VI had a higher rate at 66.25%. Further, multivariate analysis after matching demonstrated that VI was an independent risk factor for prognosis (P = .030).

Conclusion: VI is associated with multiple pathological factors and serves as an independent risk factor affecting the prognosis of GC.

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血管侵犯是胃癌的危险因素：一项回顾性分析研究。

目的：探讨胃癌（GC）患者血管侵犯（VI）与临床病理特征及预后的关系。方法：回顾性分析2014年6月至2019年6月海军医科大学第一附属医院胃肠外科行根治性胃切除术的3600例胃癌患者，根据特定的纳入和排除标准进行筛选。为了减少VI影响的选择偏倚的可能性，将患者根据是否存在VI分为两组，并进行一对一倾向评分匹配（PSM），每组724例患者。在对3205例GC患者的数据分析中，研究了不同临床病理因素下组间VI阳性的变化。采用单因素和多因素Cox回归模型探讨临床病理因素与预后的相关性。通过绘制Kaplan-Meier生存曲线进一步说明了这些发现。结果：本研究纳入3205例患者，其中vi阳性989例（30.9%），vi阴性2216例（69.1%）。VI阳性组与年龄、体重指数（BMI）、pTNM分期、肿瘤部位、神经周围浸润（PI）、Lauren分型及肿瘤沉积（TD）有显著相关性(P)。结论：VI与多种病理因素相关，是影响胃癌预后的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Surgical Oncology ONCOLOGY-SURGERY

CiteScore

4.70

自引率

15.60%

发文量

362

审稿时长

3 months

期刊介绍： World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics. Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.