The role of heart and neural crest derivatives-expressed protein factors in pregnancy

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-24 DOI:10.1016/j.bbadis.2024.167639

Chongying Zhu , Qiwei Yang , Qiang Xu , Yanhua Song , Chao Tang

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Abstract

Heart and neural crest derivatives-expressed protein 1 (HAND1) and Heart and neural crest derivatives-expressed protein 2 (HAND2), members of the Twist-family of basic Helix-Loop-Helix (bHLH) proteins, act as critical transcription factors that play a key role in various developmental processes, including placental development and fetal growth during pregnancy. This review aims to explore the current understanding of HAND1 and HAND2 in pregnant maintenance and their potential implications for maternal and fetal health. We will summarize the mechanisms of action of HAND1 and HAND2 in pregnancy, their expression regulation and association with pregnancy complications such as preterm birth and preeclampsia. Furthermore, we will discuss the potential therapeutic implications of targeting HAND1 and HAND2 in pregnancy-related disorders. This review highlights the importance of HAND1 and HAND2 in pregnancy and their potential as targets for future research and therapeutic interventions of gestational disorders.

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心脏和神经嵴衍生物表达蛋白因子在妊娠中的作用。

心脏和神经嵴衍生物表达蛋白1 （HAND1）和心脏和神经嵴衍生物表达蛋白2 （HAND2）是基础螺旋-环-螺旋（bHLH）蛋白twist家族的成员，是在妊娠期间胎盘发育和胎儿生长等多种发育过程中发挥关键作用的转录因子。本文旨在探讨目前对HAND1和HAND2在妊娠维持中的认识及其对母婴健康的潜在影响。我们将对HAND1和HAND2在妊娠中的作用机制、表达调控及其与早产、先兆子痫等妊娠并发症的关系进行综述。此外，我们将讨论靶向HAND1和HAND2在妊娠相关疾病中的潜在治疗意义。这篇综述强调了HAND1和HAND2在妊娠中的重要性，以及它们作为未来研究和妊娠疾病治疗干预的潜在目标。

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来源期刊

Biochimica et biophysica acta. Molecular basis of disease 生物-生化与分子生物学

CiteScore

12.30

自引率

0.00%

发文量

218

审稿时长

32 days

期刊介绍： BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.