Beta-Alanine for Improving Exercise Capacity, Muscle Strength, and Functional Performance of Older Adults: A Systematic Review.

Abstract

Background/objective:  Beta-alanine supplementation increases muscle carnosine content and also improves exercise capacity and performance in young adults, with mixed findings emerging from the few studies investigating its effects on older participants. Therefore, this study aimed to systematically review the evidence regarding the effects of beta-alanine on exercise capacity, muscle strength, and functional performance of older adults.

Methods:  This systematic review was conducted following the specific methodological guidelines of the Preferred Report Items for Systematic Reviews and Meta-Analyses and the Physiotherapy Evidence Database scale. Furthermore, the Cochrane risk-of-bias assessment tool was used. The search was carried out in five relevant databases (MEDLINE, Embase, Web of Science, Scopus, and Cochrane Library) from inception up to March 2024.

Results:  Of the 1,749 registers identified, only five met the established criteria and were included in this systematic review. A total of 163 older adults (mean age ± SD: 69.1 ± 2.8 years; range: 66.2-72.7 years) were included across all five studies. The majority of studies included participants from both genders. The mean intervention duration ± SD was 11.7 ± 1.0 weeks. The mean daily dosage was 2.7 ± 0.4 g/day (range: 2.4-3.2 g/day).

Conclusion:  Overall, exercise capacity may be improved following supplementation protocols with dosages ranging from 2.4 to 3.2 g/day. Muscle strength and functional performance do not seem to be improved by beta-alanine since these tasks are not significantly impacted by acidosis buildup.