The gut-brain axis: Unveiling the impact of xenobiotics on neurological health and disorders

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY Progress in Neuro-Psychopharmacology & Biological Psychiatry Pub Date : 2025-01-10 DOI:10.1016/j.pnpbp.2024.111237

Sushruta Koppula , Nitu Wankhede , Ashishkumar Kyada , Suhas Ballal , Renu Arya , Anurag Kumar Singh , Monica Gulati , Astha Sute , Sanskruti Sarode , Shruti Polshettiwar , Vaibhav Marde , Brijesh Taksande , Aman Upaganlawar , Mohammad Fareed , Milind Umekar , Spandana Rajendra Kopalli , Mayur Kale

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Abstract

The Gut-Brain Axis (GBA) is a crucial link between the gut microbiota and the central nervous system. Xenobiotics, originating from diverse sources, play a significant role in shaping this interaction. This review examines how these compounds influence neurotransmitter dynamics within the GBA. Environmental pollutants can disrupt microbial populations, impacting neurotransmitter synthesis—especially serotonin, gamma-aminobutyric acid (GABA), and dopamine pathways. Such disruptions affect mood regulation, cognition, and overall neurological function. Xenobiotics also contribute to the pathophysiology of neurological disorders, with changes in serotonin levels linked to mood disorders and imbalances in GABA and dopamine associated with anxiety, stress, and reward pathway disorders. These alterations extend beyond the GBA, leading to complications in neurological health, including increased risk of neurodegenerative diseases due to neuroinflammation triggered by neurotransmitter imbalances. This review provides a comprehensive overview of how xenobiotics influence the GBA and their implications for neurological well-being.

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肠脑轴：揭示外源性药物对神经系统健康和疾病的影响。

肠脑轴（GBA）是肠道微生物群和中枢神经系统之间的关键联系。来自不同来源的异种生物在形成这种相互作用中起着重要作用。这篇综述探讨了这些化合物如何影响大湾区内的神经递质动力学。环境污染物可以破坏微生物种群，影响神经递质合成——尤其是血清素、γ -氨基丁酸（GABA）和多巴胺途径。这种干扰会影响情绪调节、认知和整体神经功能。异种生物制剂也有助于神经系统疾病的病理生理学，血清素水平的变化与情绪障碍有关，GABA和多巴胺的失衡与焦虑、压力和奖励通路障碍有关。这些改变延伸到大湾区以外，导致神经系统健康并发症，包括神经递质失衡引发的神经炎症导致神经退行性疾病风险增加。本文综述了外源药物如何影响大湾区及其对神经系统健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Neuro-Psychopharmacology & Biological Psychiatry 医学-精神病学

CiteScore

12.00

自引率

1.80%

发文量

153

审稿时长

56 days

期刊介绍： Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.