Nonlinear association between admission oxygen partial pressure and in-hospital and one-year all-cause mortality in patients with coronavirus disease pneumonia: A retrospective cohort study.

IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Science Progress Pub Date : 2024-10-01 DOI:10.1177/00368504241310737
Ruoqing Zhou, Dianzhu Pan
{"title":"Nonlinear association between admission oxygen partial pressure and in-hospital and one-year all-cause mortality in patients with coronavirus disease pneumonia: A retrospective cohort study.","authors":"Ruoqing Zhou, Dianzhu Pan","doi":"10.1177/00368504241310737","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study investigated the correlation between admission partial pressure of arterial oxygen (PaO<sub>2</sub>) levels and both in-hospital mortality and 1-year all-cause mortality among patients diagnosed with coronavirus disease (COVID-19) pneumonia.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with COVID-19 pneumonia admitted to the First Hospital of Jinzhou Medical University. Restricted cubic spline regression and logistic regression analyses were employed to assess the relation between PaO<sub>2</sub> levels and the risk of in-hospital mortality and all-cause mortality within 1 year. Subgroup analyses were performed, stratified by age, sex, presence of cardiac disease, diabetes, hypertension, whether supplemental oxygen was provided during arterial blood gas analysis, and severity of pneumonia.</p><p><strong>Results: </strong>The study included 737 participants with in-hospital and 1-year all-cause mortality rates of 15.7% and 26.7%, respectively. Restricted cubic spline analysis revealed an L-shaped association between admission PaO<sub>2</sub> levels and in-hospital mortality (<i>P</i> nonlinear <0.001) and a U-shaped relation with 1-year all-cause mortality (<i>P</i> nonlinear <0.001), with a nadir risk of 82 mmHg. Threshold analyses indicated an odds ratio of 0.931 (95% confidence interval (CI): 0.91-0.952) for in-hospital mortality and 0.951 (95% CI: 0.933-0.969) for 1-year all-cause mortality when PaO<sub>2</sub> was <82 mmHg. Conversely, when PaO<sub>2</sub> was ≥82 mmHg, the odds ratio for in-hospital mortality was 1.022 (95% CI: 0.991-1.055), and for 1-year all-cause mortality was 1.029 (95% CI: 1.004-1.054).</p><p><strong>Conclusions: </strong>This study revealed a nonlinear relation between PaO<sub>2</sub> levels at admission and both in-hospital mortality and 1-year all-cause mortality in patients with COVID-19 pneumonia, with a notable inflection point observed at approximately 82 mmHg.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241310737"},"PeriodicalIF":2.6000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686722/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science Progress","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1177/00368504241310737","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Background: This study investigated the correlation between admission partial pressure of arterial oxygen (PaO2) levels and both in-hospital mortality and 1-year all-cause mortality among patients diagnosed with coronavirus disease (COVID-19) pneumonia.

Methods: This retrospective cohort study included patients with COVID-19 pneumonia admitted to the First Hospital of Jinzhou Medical University. Restricted cubic spline regression and logistic regression analyses were employed to assess the relation between PaO2 levels and the risk of in-hospital mortality and all-cause mortality within 1 year. Subgroup analyses were performed, stratified by age, sex, presence of cardiac disease, diabetes, hypertension, whether supplemental oxygen was provided during arterial blood gas analysis, and severity of pneumonia.

Results: The study included 737 participants with in-hospital and 1-year all-cause mortality rates of 15.7% and 26.7%, respectively. Restricted cubic spline analysis revealed an L-shaped association between admission PaO2 levels and in-hospital mortality (P nonlinear <0.001) and a U-shaped relation with 1-year all-cause mortality (P nonlinear <0.001), with a nadir risk of 82 mmHg. Threshold analyses indicated an odds ratio of 0.931 (95% confidence interval (CI): 0.91-0.952) for in-hospital mortality and 0.951 (95% CI: 0.933-0.969) for 1-year all-cause mortality when PaO2 was <82 mmHg. Conversely, when PaO2 was ≥82 mmHg, the odds ratio for in-hospital mortality was 1.022 (95% CI: 0.991-1.055), and for 1-year all-cause mortality was 1.029 (95% CI: 1.004-1.054).

Conclusions: This study revealed a nonlinear relation between PaO2 levels at admission and both in-hospital mortality and 1-year all-cause mortality in patients with COVID-19 pneumonia, with a notable inflection point observed at approximately 82 mmHg.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
冠状病毒肺炎患者入院氧分压与住院及一年全因死亡率的非线性关系:一项回顾性队列研究
背景:本研究探讨了冠状病毒病(COVID-19)肺炎患者入院时动脉氧分压(PaO2)水平与住院死亡率和1年全因死亡率的相关性。方法:回顾性队列研究纳入锦州医学院第一医院收治的COVID-19肺炎患者。采用限制三次样条回归和logistic回归分析评估PaO2水平与1年内住院死亡率和全因死亡率风险的关系。进行亚组分析,按年龄、性别、是否存在心脏病、糖尿病、高血压、动脉血气分析时是否提供补充氧气以及肺炎的严重程度进行分层。结果:该研究纳入了737名住院和1年全因死亡率分别为15.7%和26.7%的参与者。限制三次样条分析显示入院PaO2水平与住院死亡率呈l型相关(P非线性P非线性2 = 2≥82 mmHg),住院死亡率的优势比为1.022 (95% CI: 0.991-1.055), 1年全因死亡率的优势比为1.029 (95% CI: 1.004-1.054)。结论:本研究揭示了入院时PaO2水平与COVID-19肺炎患者住院死亡率和1年全因死亡率之间存在非线性关系,并在约82 mmHg处观察到一个显著的拐点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Science Progress
Science Progress Multidisciplinary-Multidisciplinary
CiteScore
3.80
自引率
0.00%
发文量
119
期刊介绍: Science Progress has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers'' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field.
期刊最新文献
Noninvasive prediction of coronary artery disease severity: Comparative analysis of electrocardiographic findings and risk factors with SYNTAX and Gensini score. Peak serum lactate as a robust predictor of imminent death in life-sustaining treatment decisions: A study of 73,927 patients. Remarkable results of energy consumption and CO2 emissions for gasoline and electric powered vehicle. Advantages of the standardized use of preoperative fascia iliaca block versus conventional analgesia in older adults with fragility hip fracture: A retrospective cohort study at two hospitals in Colombia. Lurker: Backdoor attack-based explainable rumor detection on online media.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1