No Association of Polycystic Ovary Syndrome with Pancreatic Cancer: A Mendelian Randomization Study.

IF 6.2 Q2 GENETICS & HEREDITY Phenomics (Cham, Switzerland) Pub Date : 2024-09-19 eCollection Date: 2024-10-01 DOI:10.1007/s43657-024-00156-y

Xueying Gao, Yuteng Wang, Yikun Wang, Ziyi Yang, Xueqi Yan, Shumin Li, Yonghui Jiang, Yimeng Li, Shigang Zhao, Han Zhao, Zi-Jiang Chen

{"title":"No Association of Polycystic Ovary Syndrome with Pancreatic Cancer: A Mendelian Randomization Study.","authors":"Xueying Gao, Yuteng Wang, Yikun Wang, Ziyi Yang, Xueqi Yan, Shumin Li, Yonghui Jiang, Yimeng Li, Shigang Zhao, Han Zhao, Zi-Jiang Chen","doi":"10.1007/s43657-024-00156-y","DOIUrl":null,"url":null,"abstract":"Recently, there has been a debate regarding the association between polycystic ovary syndrome (PCOS) and pancreatic cancer (PC). In order to examine the causal relationship between PCOS and PC, we conducted a Mendelian randomization study, which utilized 12 single nucleotide polymorphisms (SNPs) identified from a genome-wide association study (GWAS) meta-analysis that included 10,074 PCOS cases and 103,164 controls of European ancestry as instrumental variables (IVs). The outcome data were obtained from the FinnGen database (including 605 cases and 218,187 controls). We demonstrate that genetically predicted PCOS is not causally associated with PC risk in Europeans (odds ratio = 0.99, 95% confidence interval (CI) = 0.72-1.36, p > 0.05). Sensitivity analysis showed horizontal pleiotropy (intercept p > 0.05), heterogeneity (Cochran Q p > 0.05), and the leave-one-out sensitivity test showed that individual SNP effects had no influence on the results. In conclusion, our study did not provide evidence of a causal link between PCOS and PC.Supplementary information: The online version contains supplementary material available at 10.1007/s43657-024-00156-y.","PeriodicalId":74435,"journal":{"name":"Phenomics (Cham, Switzerland)","volume":"4 5","pages":"522-524"},"PeriodicalIF":6.2000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666843/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phenomics (Cham, Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s43657-024-00156-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

Abstract

Recently, there has been a debate regarding the association between polycystic ovary syndrome (PCOS) and pancreatic cancer (PC). In order to examine the causal relationship between PCOS and PC, we conducted a Mendelian randomization study, which utilized 12 single nucleotide polymorphisms (SNPs) identified from a genome-wide association study (GWAS) meta-analysis that included 10,074 PCOS cases and 103,164 controls of European ancestry as instrumental variables (IVs). The outcome data were obtained from the FinnGen database (including 605 cases and 218,187 controls). We demonstrate that genetically predicted PCOS is not causally associated with PC risk in Europeans (odds ratio = 0.99, 95% confidence interval (CI) = 0.72-1.36, p > 0.05). Sensitivity analysis showed horizontal pleiotropy (intercept p > 0.05), heterogeneity (Cochran Q p > 0.05), and the leave-one-out sensitivity test showed that individual SNP effects had no influence on the results. In conclusion, our study did not provide evidence of a causal link between PCOS and PC.

Supplementary information: The online version contains supplementary material available at 10.1007/s43657-024-00156-y.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

多囊卵巢综合征与胰腺癌无关联：孟德尔随机研究。

近年来，关于多囊卵巢综合征（PCOS）与胰腺癌（PC）之间的关系一直存在争议。为了研究PCOS和PC之间的因果关系，我们进行了一项孟德尔随机化研究，利用从全基因组关联研究（GWAS）荟萃分析中发现的12个单核苷酸多态性（snp）作为工具变量（IVs），其中包括10074例PCOS病例和103164例欧洲血统的对照。结果数据来自FinnGen数据库（包括605例病例和218187例对照）。我们证明遗传预测的PCOS与欧洲人的PC风险没有因果关系（优势比= 0.99,95%置信区间(CI) = 0.72-1.36, p < 0.05）。敏感性分析显示水平多效性（截距p > 0.05）、异质性（Cochran Q p > 0.05），留一敏感性检验显示个体SNP效应对结果无影响。总之，我们的研究没有提供PCOS和PC之间因果关系的证据。补充信息：在线版本包含补充资料，下载地址：10.1007/s43657-024-00156-y。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Phenomics (Cham, Switzerland)

自引率

0.00%

发文量