Childhood trauma and dissociation in patients with panic disorder, obsessive-compulsive disorder, and borderline personality disorder. Part 1: Relationships between demographic, clinical, and psychological factors.

Neuro endocrinology letters Pub Date : 2024-12-10
Krystof Kantor, Jan Prasko, Marie Ociskova, Jakub Vanek, Frantisek Hodny, Kamila Belohradova, Antonin Kolek, Jozef Visnovsky, Vlastimil Nesnídal
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Abstract

Introduction: Panic disorder (PD), obsessive-compulsive disorder (OCD), and borderline personality disorder (BPD) are associated with various psychosocial factors that may influence their onset and psychopathology. Dissociation encompasses a wide range of manifestations, from benign experiences to severe mental health issues. Research comparing childhood trauma and dissociation, general psychopathology, and the onset of the disorder among patients with PD, OCD, and BPD has not yet been published.

Results: The severity of dissociative symptoms negatively correlated with the onset of the disorder, whereas it positively correlated with the disorder's overall severity and general symptomatology. Patients with more severe childhood trauma had an earlier onset of the disorder and more severe depressive and dissociative symptoms. They rated higher on the overall severity of the disorder. Physical abuse and neglect were associated with more severe PD, OCD, and BPD. Patients with BPD had higher levels of dissociation than those with PD or OCD. BPD was also connected with more severe childhood trauma than PD and OCD patients. Comorbidity exacerbated the severity of the psychiatric disorders.

Conclusions: Childhood trauma and dissociation play a significant role in anxiety and depressive symptoms in patients with PD, OCD, and BPD.

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惊恐障碍、强迫症和边缘型人格障碍患者的童年创伤和分离。第一部分:人口学、临床和心理因素之间的关系。
惊恐障碍(PD)、强迫症(OCD)和边缘型人格障碍(BPD)与多种社会心理因素相关,这些因素可能影响其发病和精神病理。分离包括广泛的表现,从良性的经历到严重的精神健康问题。比较PD、OCD和BPD患者的童年创伤和分离、一般精神病理学和疾病发病的研究尚未发表。结果:分离症状的严重程度与障碍的发病呈负相关,而与障碍的总体严重程度和一般症状呈正相关。儿童期创伤较严重的患者发病较早,抑郁和解离症状较严重。他们对这种障碍的总体严重程度的评价更高。身体虐待和忽视与更严重的PD、OCD和BPD相关。BPD患者比PD或OCD患者有更高的分离水平。与PD和OCD患者相比,BPD患者与更严重的儿童创伤有关。合并症加重了精神障碍的严重程度。结论:童年创伤和分离在PD、OCD和BPD患者的焦虑和抑郁症状中起重要作用。
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