Single Nucleotide Polymorphism of IL-18 (Rs 1946519) in Recurrent Aborted Iraqi Women and Its Association with Toxoplasmosis.

IF 0.9 4区医学 Q4 PARASITOLOGY Iranian Journal of Parasitology Pub Date : 2024-10-01 DOI:10.18502/ijpa.v19i4.17161

Sabreen Hadi Fadhil, Entsar Jabbar Saheb

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Abstract

Background: We aimed to shed light on the risks of elevated levels of IL-18 in aborted women with toxoplasmosis by evaluating the risk or protective function of alleles or genotypes for single nucleotide polymorphism (SNP) of IL-18 (rs 1946519), which might be related to the susceptibility to toxoplasmosis.

Methods: IL-18 levels in patient and control blood samples were determined using ELISA, and the SNP IL-18 (ra 1946519) was subjected to the high-resolution method.

Results: Compared to healthy pregnant women (HP), the IL-18 serum levels of recurrent abortion with toxoplasmosis (RAWT), recurrent abortion without toxoplasmosis (RAWOT), and healthy non-pregnant (HNP) women decreased with significant differences. Additionally, a strong association between patients and controls was found in the SNP IL-18 data. RAWT and RAWOT with the genotypes AA and AC had significantly lower IL-18 serum levels than women HP, according to the distribution of IL-18 serum levels by SNP.

Conclusion: The serum level of IL-18 varied by genotype in patients with substantial differences compared to controls, while the SNP of IL-18 has been linked as a risk factor in toxoplasmosis-infected recurrent abortion women.

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伊拉克反复流产妇女IL-18 （rs1946519）单核苷酸多态性及其与弓形虫病的关系

背景：我们旨在通过评价IL-18单核苷酸多态性（SNP）等位基因或基因型对弓形虫病易感性的风险或保护作用，揭示流产女性弓形虫病患者IL-18水平升高的风险。方法：采用ELISA法检测患者及对照血样中IL-18水平，采用高分辨率法检测IL-18 SNP （ra 1946519）。结果：与健康孕妇（HP）相比，有弓形虫病的复发流产（RAWT）、无弓形虫病的复发流产（RAWOT）和健康非妊娠妇女（HNP）血清IL-18水平均降低，差异有统计学意义。此外，在SNP IL-18数据中发现患者和对照组之间存在很强的相关性。根据IL-18的SNP分布，AA和AC基因型的RAWT和RAWOT的血清IL-18水平明显低于HP女性。结论：与对照组相比，不同基因型患者血清IL-18水平存在显著差异，而IL-18 SNP与弓形虫感染的复发性流产妇女的危险因素有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Parasitology PARASITOLOGY-

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Iranian Journal of Parasitology (IJP) is the official publication of Iranian Society of Parasitology (ISP) launched in 2006. The society was inaugurated in 1994 and pursues the improvement of the knowledge on the parasites and parasitic diseases, exchange of scientific knowledge with foreign societies, publicity activities, and consultation on the parasitic diseases, and intimate relationship among society members. The main aims of the Journal are: contribution to the field of Parasitology, including all aspects of parasites and parasitic diseases (medical and veterinary) and related fields such as Entomology which may be submitted by scientists from Iran and all over the world.