Vitamin C co-administration with artemether-lumefantrine abrogates chronic stress exacerbated Plasmodium berghei-induced sickness behaviour, inflammatory and oxidative stress responses in mice.

Abstract

This study evaluated the effects of vitamin C and artemether-lumefantrine (AL) on sickness behaviour and oxido-inflammatory response in chronically stressed mice infected with Plasmodium berghei. Sickness behaviour severity was examined with weight and assessment of mice behaviours. Results showed that stress increased parasitaemia in infected mice. Vitamin C co-administration with AL increased parasite clearance over AL alone, and modulated inflammatory cytokines (TNF-α, IL-1β, IL-10, IL-12) and antioxidant parameters in plasma and brain tissue. Conclusively, stress worsens malaria-induced sickness behaviour and up-regulates the inflammatory and oxidative stress response. Co-administration of vitamin C with AL appears to counteract these detrimental effects.